In a letter published in 2018 in The New England Journal of Medicine (https://www.nejm.org/doi/full/10.1056/NEJMc2004773), the authors described a highly drug-resistance cholera strain and warned about the possible diffusion of this strain. We described here the spread of another highly drug-resistant cholera strain that as emerged in 2019 in Yemen (https://www.nature.com/articles/s41564-023-01472-1) and has been next isolated in Lebanon in 2022 (https://www.biorxiv.org/content/10.1101/2023.11.29.569232v1). We reported the presence of this strain in Kenya in 2023 and in Tanzania, Comoros and Mayotte in 2024. This strain carry an IncC plasmid encompassing resistance gene to 3rd generation cephalosporin and azithromycin. In association with chromosomic mutations, the strain remain susceptible only to one therapeutic option as proposed by the WHO. We think that this is important to report the rapid long-distance spread of this worrying strain and emphasize the need of strains laboratory surveillance.