Rapid characterization of a Delta-Omicron SARS-CoV-2 recombinant detected in Europe - Institut Pasteur Access content directly
Preprints, Working Papers, ... Year : 2022

Rapid characterization of a Delta-Omicron SARS-CoV-2 recombinant detected in Europe

Scott Nguyen
Angela Brisbarre
  • Function : Author
Vithiagaran Gunalan
  • Function : Author
Jannik Fonager
Stephan Kemeny
  • Function : Author
Abdelali Zrhidri
  • Function : Author
Thomas Duret
  • Function : Author
Christophe Rodriguez
  • Function : Author
Slim Fourati
  • Function : Author
Jean-Michel Pawlotsky
  • Function : Author
Nicolas Capron
  • Function : Author
Hugues Leroy
  • Function : Author
Elodie Alessandri-Gradt
Florian Juszczak
  • Function : Author
Laetitia Gheysen
  • Function : Author
Véronique Brodard
  • Function : Author
Hélène Moret
  • Function : Author
Martine Bos
  • Function : Author
Matthijs Welkers
  • Function : Author
Claus Scholz
Laurence Josset
  • Function : Author
Claire Cervi
  • Function : Author
Brigitte Couzon
  • Function : Author
Stéphanie Marque-Juillet
  • Function : Author
Félix Rey
Bruno Coignard
  • Function : Author
Xavier de Lamballerie

Abstract

Abstract Recombination is a crucial process in the evolution of many organisms. Although the evolutionary reasons behind its occurrence in RNA viruses are debated, this phenomenon has been associated with major epidemiological events such as virus host range expansion, antigenic shift or variation in virulence 1,2, and this process occurs frequently in positive strand RNA viruses such as coronaviruses. The SARS-CoV-2 pandemic has been associated with the repeated emergence of variants of concern presenting increased transmissibility, severity or immune escape 3. The recent extensive circulation of Delta worldwide and its subsequent replacement by viruses of the Omicron lineage 4 (BA.1 then BA.2), have created conditions for genetic exchanges between viruses with both genetic diversity and phenotypic specificities 5-7. Here we report the identification and in vitro and in vivo characterization of a Delta-Omicron recombinant in Europe. This recombinant exhibits immune escape properties similar to Omicron, while its behavior in mice expressing the human ACE2 receptor is more similar to Delta. This recombinant provides a unique and natural opportunity to better understand the genotype to phenotype links in SARS-CoV-2.
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pasteur-04067089 , version 1 (13-04-2023)

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Etienne Simon-Loriere, Xavier Montagutelli, Frederic Lemoine, Flora Donati, Franck Touret, et al.. Rapid characterization of a Delta-Omicron SARS-CoV-2 recombinant detected in Europe. 2022. ⟨pasteur-04067089⟩
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