%0 Unpublished work %T Rapid characterization of a Delta-Omicron SARS-CoV-2 recombinant detected in Europe %+ Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses %+ Génétique de la souris - Mouse Genetics %+ Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur) %+ Unité des Virus Emergents (UVE) %+ Santé publique France - French National Public Health Agency [Saint-Maurice, France] %+ University of Copenhagen = Københavns Universitet (UCPH) %+ Gen-Bio %+ Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)) %+ Plateforme de Microbiologie Mutualisée - Mutualized Platform for Microbiology (P2M) %+ Robert Koch Institute [Berlin] (RKI) %+ CHU Lyon %+ Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB %+ Virologie Structurale - Structural Virology %+ ANRS - Maladies infectieuses émergentes (ANRS - MIE) %+ Centre Hospitalier de Laval (CH Laval) %A Simon-Loriere, Etienne %A Montagutelli, Xavier %A Lemoine, Frederic %A Donati, Flora %A Touret, Franck %A Bourret, Jerome %A Prot, Matthieu %A Munier, Sandie %A Attia, Mikael %A Conquet, Laurine %A Nguyen, Scott %A Amara, Faustine %A Maisa, Anna %A Fournier, Lucie %A Brisbarre, Angela %A Dehan, Oceane %A Levillayer, Laurine %A Gunalan, Vithiagaran %A Fonager, Jannik %A Rasmussen, Morten %A Kemeny, Stephan %A Zrhidri, Abdelali %A Duret, Thomas %A Behillil, Sylvie %A Enouf, Vincent %A Rodriguez, Christophe %A Fourati, Slim %A Pawlotsky, Jean-Michel %A Capron, Nicolas %A Leroy, Hugues %A Alessandri-Gradt, Elodie %A Juszczak, Florian %A Gheysen, Laetitia %A Brodard, Véronique %A Moret, Hélène %A Bos, Martine %A Welkers, Matthijs %A Scholz, Claus %A Paraskevopoulou, Sofia %A Josset, Laurence %A Cervi, Claire %A Couzon, Brigitte %A Marque-Juillet, Stéphanie %A Delaune, Deborah %A Khiari, Slim El %A Fumey, Julien %A Hallouin-Bernard, Marie-Charlotte %A Rey, Félix %A Yazdanpanah, Yazdan %A Coignard, Bruno %A de Lamballerie, Xavier %A Werf, Sylvie van Der %A Paquin, Axelle %P 589-605 %8 2022-04-04 %D 2022 %R 10.21203/rs.3.rs-1502293/v1 %Z Life Sciences [q-bio]/Santé publique et épidémiologiePreprints, Working Papers, ... %X Abstract Recombination is a crucial process in the evolution of many organisms. Although the evolutionary reasons behind its occurrence in RNA viruses are debated, this phenomenon has been associated with major epidemiological events such as virus host range expansion, antigenic shift or variation in virulence 1,2, and this process occurs frequently in positive strand RNA viruses such as coronaviruses. The SARS-CoV-2 pandemic has been associated with the repeated emergence of variants of concern presenting increased transmissibility, severity or immune escape 3. The recent extensive circulation of Delta worldwide and its subsequent replacement by viruses of the Omicron lineage 4 (BA.1 then BA.2), have created conditions for genetic exchanges between viruses with both genetic diversity and phenotypic specificities 5-7. Here we report the identification and in vitro and in vivo characterization of a Delta-Omicron recombinant in Europe. This recombinant exhibits immune escape properties similar to Omicron, while its behavior in mice expressing the human ACE2 receptor is more similar to Delta. This recombinant provides a unique and natural opportunity to better understand the genotype to phenotype links in SARS-CoV-2. %G English %2 https://pasteur.hal.science/pasteur-04067089/document %2 https://pasteur.hal.science/pasteur-04067089/file/21d994f6-515b-41ee-9f54-7193cd68952d.pdf %L pasteur-04067089 %U https://pasteur.hal.science/pasteur-04067089 %~ IRD %~ PASTEUR %~ HCL %~ CNRS %~ UNIV-AMU %~ ANRS %~ SANTE_PUB_INSERM %~ UNIV-PARIS %~ UNIVERSITE-PARIS %~ UP-SCIENCES %~ VIR-STRUCT %~ PASTEUR_UMR3569 %~ GMV-ARN %~ FRANCE-GENOMIQUE %~ BIOINFO_BIOSTAT_HUB