Article Dans Une Revue F1000Research Année : 2021

ELIXIR and Toxicology: a community in development

1 Maastricht UMC+ - Maastricht University Medical Center+
2 TNO - The Netherlands Organisation for Applied Scientific Research
3 LCSB - Luxembourg Centre For Systems Biomedicine
4 NKUA - National and Kapodistrian University of Athens
5 BAS - Bulgarian Academy of Sciences = Académie bulgare des sciences [Académie des sciences de Bulgarie] = Българска академия на науките
6 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
7 T3S - UMR_S 1124 - Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
8 RECETOX / MUNI - Research Centre for Toxic Compounds in the Environment [Brno]
9 Palacky University Olomouc
10 VITO - Flemish Institute for Technological Research
11 NCBI - National Center for Biotechnology Information
12 Chemotargets SL
13 GSFC University
14 Forschungs- und Beratungsinstitut Gefahrstoffe GmbH (FoBiG)
15 Seven Past Nine
16 VU - Vrije Universiteit Amsterdam [Amsterdam]
17 Karolinska Institutet = Karolinska Institute [Stockholm]
18 Misvik Biology
19 HWU - Heriot-Watt University [Edinburgh]
20 ELIXIR Hub [Cambridge]
21 Goethe University Frankfurt = Goethe-Universität Frankfurt am Main
22 Ideaconsult
23 Maastricht University [Maastricht]
24 ToxAlim-MeX - Métabolisme et Xénobiotiques
25 MetaboHUB-MetaToul
26 FMPOS - Faculté de Médecine, de pharmacie et d’Odonto-Stomatologie [Bamako, Mali]
27 University of Birmingham [Birmingham]
28 Tartu University Hospital
29 AstraZeneca [Cambridge, UK]
30 Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB
31 IFB-core - Institut Français de Bioinformatique
32 IPB - Leibniz Institute of Plant Biochemistry
33 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
34 URV - University Rovira i virgili = Universidad Rovira y Virgili = Universitat Rovira i Virgili
35 University of Oxford
36 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
37 University of York [York, UK]
38 UPF - Universitat Pompeu Fabra [Barcelona]
39 NTUA - National Technical University of Athens
40 UFZ - Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research
41 Environmental Institute Kos
42 Uppsala University
43 Leiden Academic Center for Drug Research
44 United States Environmental Protection Agency [Cincinnati]
45 Universität Wien = University of Vienna
46 NIB - National Institute of Biology [Ljubljana]
Marvin Martens
Kirtan Dave
  • Fonction : Auteur
Thomas Exner
  • Fonction : Auteur
Nina Jeliazkova
  • Fonction : Auteur
Pascal Kahlem
  • Fonction : Auteur
Iseult Lynch
Sergio Martinez Cuesta
Philippe Rocca-Serra
Susanna-Assunta Sansone
Sirarat Sarntivijai
Ola Spjuth
Egon Willighagen

Résumé

Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For example, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.

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Dates et versions

pasteur-03680151 , version 1 (27-05-2022)

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Marvin Martens, Rob Stierum, Emma Schymanski, Chris Evelo, Reza Aalizadeh, et al.. ELIXIR and Toxicology: a community in development. F1000Research, 2021, 10, pp.1129. ⟨10.12688/f1000research.74502.1⟩. ⟨pasteur-03680151⟩
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