Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids - Institut Pasteur Access content directly
Journal Articles Nature Genetics Year : 2019

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Amy R. Bentley (1) , Yun J. Sung (2) , Michael R. Brown (3) , Thomas W. Winkler (4) , Aldi T. Kraja (2) , Ioanna Ntalla (5) , Karen Schwander (2) , Daniel I. Chasman (6, 7) , Elise Lim (8) , Xuan Deng (8) , Xiuqing Guo (9) , Jingmin Liu (10) , Yingchang Lu (11) , Ching-Yu Cheng (12, 13, 14) , Xueling Sim (14) , Dina Vojinovic (15) , Jennifer E. Huffman (16) , Solomon K. Musani (17) , Changwei Li (18) , Mary F. Feitosa (2) , Melissa A. Richard (3) , Raymond Noordam (19) , Jenna Baker (1) , Guanjie Chen (1) , Hugues Aschard (20, 21) , Traci M. Bartz (22) , Jingzhong Ding (23) , Rajkumar Dorajoo (24) , Alisa K. Manning (25, 7) , Tuomo Rankinen (26) , Albert V. Smith (27, 28) , Salman M. Tajuddin (1) , Wei Zhao (29) , Mariaelisa Graff (30) , Maris Alver (31) , Mathilde Boissel (32) , Jin Fang Chai (14) , Xu Chen (33) , Jasmin Divers (34) , Evangelos Evangelou (35, 36) , Chuan Gao (34) , Anuj Goel (37) , Yanick Hagemeijer (38) , Sarah E. Harris (16) , Fernando P. Hartwig (39, 40) , Meian He (41) , Andrea R. V. R. Horimoto (42) , Fang-Chi Hsu (34) , Yi-Jen Hung , Anne Jackson , Anuradhani Kasturiratne , Pirjo Komulainen , Brigitte Kühnel , Karin Leander , Keng-Hung Lin , Jian'An Luan , Leo-Pekka Lyytikäinen , Nana Matoba , Ilja Nolte , Maik Pietzner , Bram Prins , Muhammad Riaz , Antonietta Robino , M. Abdullah Said (38) , Nicole Schupf , Robert Scott , Tamar Sofer (7) , Alena Stancáková , Fumihiko Takeuchi , Bamidele Tayo , Peter van Der Most , Tibor Varga , Tzung-Dau Wang , Yajuan Wang , Erin Ware , Wanqing Wen , Yong-Bing Xiang , Lisa Yanek , Weihua Zhang , Jing Hua Zhao , Adebowale Adeyemo (1) , Saima Afaq , Najaf Amin (15) , Marzyeh Amini , Dan Arking , Zorayr Arzumanyan (9) , Tin Aung (12, 14) , Christie Ballantyne , R Graham Barr , Lawrence F. Bielak (29) , Eric Boerwinkle (3) , Erwin P. Bottinger (11) , Ulrich Broeckel , Morris Brown (5) , Brian Cade , Archie Campbell , Mickaël Canouil (32) , Sabanayagam Charumathi (12, 13) , Yii-Der Ida Chen (9) , Kaare Christensen , Maria Pina Concas , John Connell , Lisa de Las Fuentes (2) , H Janaka de Silva , Paul S. de Vries (3) , Ayo Doumatey (1) , Qing Duan , Charles Eaton , Ruben N. Eppinga (38) , Jessica Faul , James S. Floyd (22) , Nita Forouhi , Terrence Forrester , Yechiel Friedlander , Ilaria Gandin , He Gao (35) , Mohsen Ghanbari (15) , Sina Gharib , Bruna Gigante , Franco Giulianini (6) , Hans Grabe , C. Charles Gu (2) , Tamara Harris , Sami Heikkinen , Chew-Kiat Heng , Makoto Hirata , James E. Hixson (3) , M. Arfan Ikram (15) , Yucheng Jia (9) , Roby Joehanes , Craig Johnson , Jost Bruno Jonas , Anne E. Justice (30) , Tomohiro Katsuya , Chiea Chuen Khor (24) , Tuomas Kilpeläinen , Woon-Puay Koh (14) , Ivana Kolcic , Charles Kooperberg , Jose E. Krieger (42) , Stephen Kritchevsky , Michiaki Kubo , Johanna Kuusisto , Timo Lakka , Carl D. Langefeld (34) , Claudia Langenberg , Lenore Launer , Benjamin Lehne , Cora Lewis , Yize Li (2) , Jingjing Liang , Shiow Lin (2) , Ching-Ti Liu (8) , Jianjun Liu (24) , Kiang Liu , Marie Loh , Kurt K. Lohman (34) , Tin Louie , Anna Luzzi (9) , Reedik Mägi (31) , Anubha Mahajan (37) , Ani Manichaikul , Colin Mckenzie , Thomas Meitinger , Andres Metspalu (31) , Yuri Milaneschi , Lili Milani (31) , Karen Mohlke , Yukihide Momozawa , Andrew P. Morris (37) , Alison Murray , Mike Nalls , Matthias Nauck , Christopher Nelson , Kari E. North (30) , Jeffrey O'Connell , Nicholette Palmer , George Papanicolau , Nancy L. Pedersen (33) , Annette Peters , Patricia A. Peyser (29) , Ozren Polasek , Neil Poulter , Olli Raitakari , Alex Reiner , Frida Renström , Treva K. Rice (2) , Stephen Rich , Jennifer Robinson , Lynda M. Rose (6) , Frits Rosendaal , Igor Rudan , Carsten Schmidt , Pamela Schreiner , William Scott , Peter Sever , Yuan Shi (12) , Stephen Sidney , Mario Sims (17) , Jennifer A. Smith (29) , Harold Snieder , John M. Starr (16) , Konstantin Strauch , Heather Stringham , Nicholas Y. Q. Tan (12) , Hua Tang , Kent D. Taylor (9) , Yik Ying Teo (14, 24) , Yih Chung Tham (12) , Henning Tiemeier (15) , Stephen Turner , André G. Uitterlinden (15) , Diana van Heemst (19) , Melanie Waldenberger , Heming Wang (7) , Lan Wang (8) , Lihua Wang (2) , Wen Bin Wei , Christine A. Williams (2) , Gregory Wilson , Mary K. Wojczynski (2) , Jie Yao (9) , Kristin Young (30) , Caizheng Yu (41) , Jian-Min Yuan , Jie Zhou (1) , Alan Zonderman , Diane Becker , Michael Boehnke , Donald Bowden , John C. Chambers (35) , Richard Cooper , Ulf de Faire , Ian J. Deary (16) , Paul Elliott , Tõnu Esko (31) , Martin Farrall (37) , Paul Franks , Barry Freedman , Philippe Froguel (32) , Paolo Gasparini , Christian Gieger , Bernardo L. Horta (39) , Jyh-Ming Jimmy Juang , Yoichiro Kamatani , Candace Kammerer , Norihiro Kato , Jaspal Kooner , Markku Laakso , Cathy Laurie , I-Te Lee , Terho Lehtimäki , Patrik K. E. Magnusson (33) , Albertine Oldehinkel , Brenda Penninx , Alexandre C. Pereira (42) , Rainer Rauramaa , Susan Redline , Nilesh Samani , James Scott , Xiao-Ou Shu , Pim van Der Harst (38) , Lynne Wagenknecht , Jun-Sing Wang , Ya Xing Wang , Nicholas Wareham , Hugh Watkins (37) , David Weir , Ananda Wickremasinghe , Tangchun Wu (41) , Eleftheria Zeggini , Wei Zheng , Claude Bouchard (26) , Michele K. Evans (1) , Vilmundur Gudnason (27, 28) , Sharon L. R. Kardia (29) , Yongmei Liu , Bruce M. Psaty (22) , Paul M. Ridker (6, 7) , Rob M. van Dam (14) , Dennis Mook-Kanamori , Myriam Fornage (3) , Michael A. Province (2) , Tanika Kelly , Ervin Fox , Caroline Hayward (16) , Cornelia M. van Duijn (15) , E. Shyong Tai (14) , Tien Yin Wong (12, 14) , Ruth J. F. Loos (11) , Nora Franceschini (30) , Jerome I. Rotter (9) , Xiaofeng Zhu (43) , Laura J. Bierut (2) , W. James Gauderman (44) , Kenneth Rice (22) , Patricia B. Munroe (5) , Alanna C. Morrison (3) , Dabeeru C. Rao (2) , Charles N. Rotimi (1) , L. Adrienne Cupples (8)
1 NIH - National Institutes of Health [Bethesda]
2 Washington University School of Medicine in St. Louis
3 UTHealth - The University of Texas Health Science Center at Houston
4 UR - Universität Regensburg
5 QMUL - Queen Mary University of London
6 Brigham and Women's Hospital [Boston]
7 HMS - Harvard Medical School [Boston]
8 School of Public Health [Boston]
9 LA BioMed - Los Angeles Biomedical Research Institute
10 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
11 MSSM - Icahn School of Medicine at Mount Sinai [New York]
12 SERI - Singapore Eye Research Institute [Singapore]
13 Duke-NUS Medical School [Singapore]
14 NUS - National University of Singapore
15 Erasmus MC - Erasmus University Medical Center [Rotterdam]
16 University of Edinburgh
17 UMMC - University of Mississippi Medical Center
18 University of Georgia [USA]
19 LUMC - Leiden University Medical Center
20 C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative
21 Harvard T.H. Chan School of Public Health
22 University of Washington [Seattle]
23 Wake Forest University
24 GIS - Genome Institute of Singapore
25 Massachusetts General Hospital [Boston]
26 Pennington Biomedical Research Center
27 IHA - Icelandic Heart Association [Kopavogur, Iceland]
28 University of Iceland [Reykjavik]
29 University of Michigan [Ann Arbor]
30 UNC - University of North Carolina [Chapel Hill]
31 University of Tartu
32 EGENODIA (GI3M) - Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283
33 Karolinska Institutet [Stockholm]
34 Wake Forest School of Medicine [Winston-Salem]
35 Imperial College London
36 University of Ioannina
37 University of Oxford
38 University of Groningen [Groningen]
39 UFPel - Universidade Federal de Pelotas = Federal University of Pelotas
40 University of Bristol [Bristol]
41 HUST - Huazhong University of Science and Technology [Wuhan]
42 FMUSP - Universidade de São Paulo Medical School
43 Case Western Reserve University [Cleveland]
44 USC - University of Southern California
Rajkumar Dorajoo
Maris Alver
  • Function : Author
Anuj Goel
  • Function : Author
Yi-Jen Hung
  • Function : Author
Anne Jackson
  • Function : Author
Anuradhani Kasturiratne
  • Function : Author
Pirjo Komulainen
  • Function : Author
Brigitte Kühnel
  • Function : Author
Karin Leander
Keng-Hung Lin
  • Function : Author
Jian'An Luan
  • Function : Author
Leo-Pekka Lyytikäinen
  • Function : Author
Nana Matoba
  • Function : Author
Ilja Nolte
  • Function : Author
Maik Pietzner
  • Function : Author
Bram Prins
  • Function : Author
Muhammad Riaz
  • Function : Author
Antonietta Robino
  • Function : Author
Nicole Schupf
  • Function : Author
Robert Scott
  • Function : Author
Alena Stancáková
  • Function : Author
Fumihiko Takeuchi
  • Function : Author
Bamidele Tayo
  • Function : Author
Peter van Der Most
  • Function : Author
Tibor Varga
Tzung-Dau Wang
  • Function : Author
Yajuan Wang
  • Function : Author
Erin Ware
  • Function : Author
Wanqing Wen
  • Function : Author
Yong-Bing Xiang
  • Function : Author
Lisa Yanek
  • Function : Author
Weihua Zhang
  • Function : Author
Jing Hua Zhao
  • Function : Author
Saima Afaq
  • Function : Author
Marzyeh Amini
  • Function : Author
Dan Arking
  • Function : Author
Christie Ballantyne
  • Function : Author
R Graham Barr
  • Function : Author
Ulrich Broeckel
  • Function : Author
Brian Cade
  • Function : Author
Archie Campbell
  • Function : Author
Kaare Christensen
  • Function : Author
Maria Pina Concas
  • Function : Author
John Connell
  • Function : Author
H Janaka de Silva
  • Function : Author
Qing Duan
  • Function : Author
Charles Eaton
  • Function : Author
Jessica Faul
  • Function : Author
Nita Forouhi
  • Function : Author
Terrence Forrester
  • Function : Author
Yechiel Friedlander
  • Function : Author
Ilaria Gandin
  • Function : Author
He Gao
  • Function : Author
Sina Gharib
  • Function : Author
Bruna Gigante
  • Function : Author
Hans Grabe
  • Function : Author
Tamara Harris
  • Function : Author
Sami Heikkinen
  • Function : Author
Chew-Kiat Heng
  • Function : Author
Makoto Hirata
  • Function : Author
Roby Joehanes
  • Function : Author
Craig Johnson
  • Function : Author
Jost Bruno Jonas
  • Function : Author
Tomohiro Katsuya
  • Function : Author
Chiea Chuen Khor
Tuomas Kilpeläinen
  • Function : Author
Ivana Kolcic
  • Function : Author
Charles Kooperberg
  • Function : Author
Stephen Kritchevsky
  • Function : Author
Michiaki Kubo
  • Function : Author
Johanna Kuusisto
  • Function : Author
Timo Lakka
  • Function : Author
Claudia Langenberg
  • Function : Author
Lenore Launer
  • Function : Author
Benjamin Lehne
  • Function : Author
Cora Lewis
  • Function : Author
Jingjing Liang
Jianjun Liu
Kiang Liu
  • Function : Author
Marie Loh
  • Function : Author
Tin Louie
  • Function : Author
Reedik Mägi
  • Function : Author
Ani Manichaikul
  • Function : Author
Colin Mckenzie
  • Function : Author
Thomas Meitinger
  • Function : Author
Yuri Milaneschi
  • Function : Author
Lili Milani
  • Function : Author
Karen Mohlke
  • Function : Author
Yukihide Momozawa
  • Function : Author
Alison Murray
Mike Nalls
  • Function : Author
Matthias Nauck
  • Function : Author
Christopher Nelson
  • Function : Author
Jeffrey O'Connell
  • Function : Author
Nicholette Palmer
  • Function : Author
George Papanicolau
  • Function : Author
Annette Peters
Ozren Polasek
  • Function : Author
Neil Poulter
  • Function : Author
Olli Raitakari
  • Function : Author
Alex Reiner
  • Function : Author
Frida Renström
  • Function : Author
Stephen Rich
  • Function : Author
Jennifer Robinson
  • Function : Author
Frits Rosendaal
  • Function : Author
Igor Rudan
  • Function : Author
Carsten Schmidt
  • Function : Author
Pamela Schreiner
  • Function : Author
William Scott
  • Function : Author
Peter Sever
Stephen Sidney
  • Function : Author
Harold Snieder
  • Function : Author
Konstantin Strauch
  • Function : Author
Heather Stringham
  • Function : Author
Hua Tang
  • Function : Author
Stephen Turner
  • Function : Author
Melanie Waldenberger
  • Function : Author
Wen Bin Wei
  • Function : Author
Gregory Wilson
  • Function : Author
Jian-Min Yuan
  • Function : Author
Alan Zonderman
  • Function : Author
Diane Becker
  • Function : Author
Michael Boehnke
  • Function : Author
Donald Bowden
  • Function : Author
Richard Cooper
Ulf de Faire
  • Function : Author
Paul Elliott
Tõnu Esko
  • Function : Author
Paul Franks
  • Function : Author
Barry Freedman
  • Function : Author
Paolo Gasparini
  • Function : Author
Christian Gieger
  • Function : Author
Jyh-Ming Jimmy Juang
  • Function : Author
Yoichiro Kamatani
  • Function : Author
Candace Kammerer
  • Function : Author
Norihiro Kato
  • Function : Author
Jaspal Kooner
  • Function : Author
Markku Laakso
  • Function : Author
Cathy Laurie
  • Function : Author
I-Te Lee
  • Function : Author
Terho Lehtimäki
  • Function : Author
Albertine Oldehinkel
  • Function : Author
Brenda Penninx
  • Function : Author
Rainer Rauramaa
  • Function : Author
Susan Redline
  • Function : Author
Nilesh Samani
James Scott
Xiao-Ou Shu
  • Function : Author
Lynne Wagenknecht
  • Function : Author
Jun-Sing Wang
  • Function : Author
Ya Xing Wang
  • Function : Author
Nicholas Wareham
  • Function : Author
David Weir
  • Function : Author
Ananda Wickremasinghe
  • Function : Author
Eleftheria Zeggini
  • Function : Author
Wei Zheng
Yongmei Liu
  • Function : Author
Dennis Mook-Kanamori
  • Function : Author
Tanika Kelly
  • Function : Author
Ervin Fox
  • Function : Author
E. Shyong Tai

Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Dates and versions

pasteur-03278554 , version 1 (05-07-2021)

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Cite

Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, et al.. Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 2019, 51 (4), pp.636-648. ⟨10.1038/s41588-019-0378-y⟩. ⟨pasteur-03278554⟩
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