%0 Journal Article %T Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids %+ National Institutes of Health [Bethesda] (NIH) %+ Washington University School of Medicine in St. Louis %+ The University of Texas Health Science Center at Houston (UTHealth) %+ Universität Regensburg (UR) %+ Queen Mary University of London (QMUL) %+ Brigham and Women's Hospital [Boston] %+ Harvard Medical School [Boston] (HMS) %+ School of Public Health [Boston] %+ Los Angeles Biomedical Research Institute (LA BioMed) %+ Fred Hutchinson Cancer Research Center [Seattle] (FHCRC) %+ Icahn School of Medicine at Mount Sinai [New York] (MSSM) %+ Singapore Eye Research Institute [Singapore] (SERI) %+ Duke-NUS Medical School [Singapore] %+ National University of Singapore (NUS) %+ Erasmus University Medical Center [Rotterdam] (Erasmus MC) %+ University of Edinburgh %+ University of Mississippi Medical Center (UMMC) %+ University of Georgia [USA] %+ Leiden University Medical Center (LUMC) %+ Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI) %+ Harvard T.H. Chan School of Public Health %+ University of Washington [Seattle] %+ Wake Forest University %+ Genome Institute of Singapore (GIS) %+ Massachusetts General Hospital [Boston] %+ Pennington Biomedical Research Center %+ Icelandic Heart Association [Kopavogur, Iceland] (IHA) %+ University of Iceland [Reykjavik] %+ University of Michigan [Ann Arbor] %+ University of North Carolina [Chapel Hill] (UNC) %+ University of Tartu %+ Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)) %+ Karolinska Institutet [Stockholm] %+ Wake Forest School of Medicine [Winston-Salem] %+ Imperial College London %+ University of Ioannina %+ University of Oxford %+ University of Groningen [Groningen] %+ Universidade Federal de Pelotas = Federal University of Pelotas (UFPel) %+ University of Bristol [Bristol] %+ Huazhong University of Science and Technology [Wuhan] (HUST) %+ Universidade de São Paulo Medical School (FMUSP) %+ Case Western Reserve University [Cleveland] %+ University of Southern California (USC) %A Bentley, Amy, R. %A Sung, Yun, J. %A Brown, Michael, R. %A Winkler, Thomas, W. %A Kraja, Aldi, T. %A Ntalla, Ioanna %A Schwander, Karen %A Chasman, Daniel, I. %A Lim, Elise %A Deng, Xuan %A Guo, Xiuqing %A Liu, Jingmin %A Lu, Yingchang %A Cheng, Ching-Yu %A Sim, Xueling %A Vojinovic, Dina %A Huffman, Jennifer, E. %A Musani, Solomon, K. %A Li, Changwei %A Feitosa, Mary, F. %A Richard, Melissa, A. %A Noordam, Raymond %A Baker, Jenna %A Chen, Guanjie %A Aschard, Hugues %A Bartz, Traci, M. %A Ding, Jingzhong %A Dorajoo, Rajkumar %A Manning, Alisa, K. %A Rankinen, Tuomo %A Smith, Albert, V. %A Tajuddin, Salman, M. %A Zhao, Wei %A Graff, Mariaelisa %A Alver, Maris %A Boissel, Mathilde %A Chai, Jin Fang %A Chen, Xu %A Divers, Jasmin %A Evangelou, Evangelos %A Gao, Chuan %A Goel, Anuj %A Hagemeijer, Yanick %A Harris, Sarah, E. %A Hartwig, Fernando, P. %A He, Meian %A Horimoto, Andrea, R. V. R. %A Hsu, Fang-Chi %A Hung, Yi-Jen %A Jackson, Anne %A Kasturiratne, Anuradhani %A Komulainen, Pirjo %A Kühnel, Brigitte %A Leander, Karin %A Lin, Keng-Hung %A Luan, Jian'An %A Lyytikäinen, Leo-Pekka %A Matoba, Nana %A Nolte, Ilja %A Pietzner, Maik %A Prins, Bram %A Riaz, Muhammad %A Robino, Antonietta %A Said, M. Abdullah %A Schupf, Nicole %A Scott, Robert %A Sofer, Tamar %A Stancáková, Alena %A Takeuchi, Fumihiko %A Tayo, Bamidele %A van Der Most, Peter %A Varga, Tibor %A Wang, Tzung-Dau %A Wang, Yajuan %A Ware, Erin %A Wen, Wanqing %A Xiang, Yong-Bing %A Yanek, Lisa %A Zhang, Weihua %A Zhao, Jing Hua %A Adeyemo, Adebowale %A Afaq, Saima %A Amin, Najaf %A Amini, Marzyeh %A Arking, Dan %A Arzumanyan, Zorayr %A Aung, Tin %A Ballantyne, Christie %A Barr, R Graham %A Bielak, Lawrence, F. %A Boerwinkle, Eric %A Bottinger, Erwin, P. %A Broeckel, Ulrich %A Brown, Morris %A Cade, Brian %A Campbell, Archie %A Canouil, Mickaël %A Charumathi, Sabanayagam %A Chen, Yii-Der Ida %A Christensen, Kaare %A Concas, Maria Pina %A Connell, John %A de Las Fuentes, Lisa %A de Silva, H Janaka %A de Vries, Paul, S. %A Doumatey, Ayo %A Duan, Qing %A Eaton, Charles %A Eppinga, Ruben, N. %A Faul, Jessica %A Floyd, James, S. %A Forouhi, Nita %A Forrester, Terrence %A Friedlander, Yechiel %A Gandin, Ilaria %A Gao, He %A Ghanbari, Mohsen %A Gharib, Sina %A Gigante, Bruna %A Giulianini, Franco %A Grabe, Hans %A Gu, C. Charles %A Harris, Tamara %A Heikkinen, Sami %A Heng, Chew-Kiat %A Hirata, Makoto %A Hixson, James, E. %A Ikram, M. Arfan %A Jia, Yucheng %A Joehanes, Roby %A Johnson, Craig %A Jonas, Jost Bruno %A Justice, Anne, E. %A Katsuya, Tomohiro %A Khor, Chiea Chuen %A Kilpeläinen, Tuomas %A Koh, Woon-Puay %A Kolcic, Ivana %A Kooperberg, Charles %A Krieger, Jose, E. %A Kritchevsky, Stephen %A Kubo, Michiaki %A Kuusisto, Johanna %A Lakka, Timo %A Langefeld, Carl, D. %A Langenberg, Claudia %A Launer, Lenore %A Lehne, Benjamin %A Lewis, Cora %A Li, Yize %A Liang, Jingjing %A Lin, Shiow %A Liu, Ching-Ti %A Liu, Jianjun %A Liu, Kiang %A Loh, Marie %A Lohman, Kurt, K. %A Louie, Tin %A Luzzi, Anna %A Mägi, Reedik %A Mahajan, Anubha %A Manichaikul, Ani %A Mckenzie, Colin %A Meitinger, Thomas %A Metspalu, Andres %A Milaneschi, Yuri %A Milani, Lili %A Mohlke, Karen %A Momozawa, Yukihide %A Morris, Andrew, P. %A Murray, Alison %A Nalls, Mike %A Nauck, Matthias %A Nelson, Christopher %A North, Kari, E. %A O'Connell, Jeffrey %A Palmer, Nicholette %A Papanicolau, George %A Pedersen, Nancy, L. %A Peters, Annette %A Peyser, Patricia, A. %A Polasek, Ozren %A Poulter, Neil %A Raitakari, Olli %A Reiner, Alex %A Renström, Frida %A Rice, Treva, K. %A Rich, Stephen %A Robinson, Jennifer %A Rose, Lynda, M. %A Rosendaal, Frits %A Rudan, Igor %A Schmidt, Carsten %A Schreiner, Pamela %A Scott, William %A Sever, Peter %A Shi, Yuan %A Sidney, Stephen %A Sims, Mario %A Smith, Jennifer, A. %A Snieder, Harold %A Starr, John, M. %A Strauch, Konstantin %A Stringham, Heather %A Tan, Nicholas, Y. Q. %A Tang, Hua %A Taylor, Kent, D. %A Teo, Yik Ying %A Tham, Yih Chung %A Tiemeier, Henning %A Turner, Stephen %A Uitterlinden, André, G. %A van Heemst, Diana %A Waldenberger, Melanie %A Wang, Heming %A Wang, Lan %A Wang, Lihua %A Wei, Wen Bin %A Williams, Christine, A. %A Wilson, Gregory %A Wojczynski, Mary, K. %A Yao, Jie %A Young, Kristin %A Yu, Caizheng %A Yuan, Jian-Min %A Zhou, Jie %A Zonderman, Alan %A Becker, Diane %A Boehnke, Michael %A Bowden, Donald %A Chambers, John, C. %A Cooper, Richard %A de Faire, Ulf %A Deary, Ian, J. %A Elliott, Paul %A Esko, Tõnu %A Farrall, Martin %A Franks, Paul %A Freedman, Barry %A Froguel, Philippe %A Gasparini, Paolo %A Gieger, Christian %A Horta, Bernardo, L. %A Juang, Jyh-Ming Jimmy %A Kamatani, Yoichiro %A Kammerer, Candace %A Kato, Norihiro %A Kooner, Jaspal %A Laakso, Markku %A Laurie, Cathy %A Lee, I-Te %A Lehtimäki, Terho %A Magnusson, Patrik, K. E. %A Oldehinkel, Albertine %A Penninx, Brenda %A Pereira, Alexandre, C. %A Rauramaa, Rainer %A Redline, Susan %A Samani, Nilesh %A Scott, James %A Shu, Xiao-Ou %A van Der Harst, Pim %A Wagenknecht, Lynne %A Wang, Jun-Sing %A Wang, Ya Xing %A Wareham, Nicholas %A Watkins, Hugh %A Weir, David %A Wickremasinghe, Ananda %A Wu, Tangchun %A Zeggini, Eleftheria %A Zheng, Wei %A Bouchard, Claude %A Evans, Michele, K. %A Gudnason, Vilmundur %A Kardia, Sharon, L. R. %A Liu, Yongmei %A Psaty, Bruce, M. %A Ridker, Paul, M. %A van Dam, Rob, M. %A Mook-Kanamori, Dennis %A Fornage, Myriam %A Province, Michael, A. %A Kelly, Tanika %A Fox, Ervin %A Hayward, Caroline %A van Duijn, Cornelia, M. %A Tai, E. Shyong %A Wong, Tien Yin %A Loos, Ruth, J. F. %A Franceschini, Nora %A Rotter, Jerome, I. %A Zhu, Xiaofeng %A Bierut, Laura, J. %A Gauderman, W. James %A Rice, Kenneth %A Munroe, Patricia, B. %A Morrison, Alanna, C. %A Rao, Dabeeru, C. %A Rotimi, Charles, N. %A Cupples, L. Adrienne %Z This project was largely supported by a grant from the US National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL118305) and by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (Z01HG200362). %< avec comité de lecture %@ 1061-4036 %J Nature Genetics %I Nature Publishing Group %V 51 %N 4 %P 636-648 %8 2019-03-29 %D 2019 %R 10.1038/s41588-019-0378-y %M 30926973 %Z Life Sciences [q-bio]/Genetics/Human genetics %Z Life Sciences [q-bio]/Santé publique et épidémiologie %Z Statistics [stat]/Methodology [stat.ME] %Z Statistics [stat]/Applications [stat.AP] %Z Computer Science [cs]/Bioinformatics [q-bio.QM]Journal articles %X The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. %G English %L pasteur-03278554 %U https://pasteur.hal.science/pasteur-03278554 %~ PASTEUR %~ RIIP %~ CNRS %~ SANTE_PUB_INSERM %~ RIIP_LILLE %~ UNIV-LILLE %~ TEST-HALCNRS