A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis - Institut Pasteur Access content directly
Preprints, Working Papers, ... Year : 2021

A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

Pedro Goncalves
James P. Di Santo
Hugo Mouquet
Olivier Schwartz
Aurélien Corneau
Damien Bonnet

Abstract

SARS-CoV-2 infection in children is generally milder than in adults, yet a proportion of cases result in hyperinflammatory conditions often including myocarditis. To better understand these cases, we applied a multi-parametric approach to the study of blood cells of 56 children hospitalized with suspicion of SARS-CoV-2 infection. The most severe forms of MIS-C (multisystem inflammatory syndrome in children related to SARS-CoV-2), that resulted in myocarditis, were characterized by elevated levels of pro-angiogenesis cytokines and several chemokines. Single-cell transcriptomic analyses identified a unique monocyte/dendritic cell gene signature that correlated with the occurrence of severe myocarditis, characterized by sustained NF-κB activity, TNF-α signaling, associated with decreased gene expression of NF-κB inhibitors. We also found a weak response to type-I and type-II interferons, hyperinflammation and response to oxidative stress related to increased HIF-1α and VEGF signaling. These results provide potential for a better understanding of disease pathophysiology.

Domains

Immunology
Fichier principal
Vignette du fichier
2021.02.23.432486v1.full.pdf (16.26 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-03244400 , version 1 (01-06-2021)

Licence

Copyright

Identifiers

Cite

Camille de Cevins, Marine Luka, Nikaïa Smith, Sonia Meynier, Aude Magérus, et al.. A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis. 2021. ⟨pasteur-03244400⟩
348 View
213 Download

Altmetric

Share

Gmail Facebook X LinkedIn More