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Journal Articles Structure Year : 2020

Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry

1 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
2 Universiteit Utrecht / Utrecht University [Utrecht]
3 UVIC - University of Victoria [Canada]
4 Lady Davis Institute for Medical Research [Montréal]
5 Skoltech - Skolkovo Institute of Science and Technology [Moscow]
6 UC San Francisco - University of California [San Francisco]
7 UTechS MSBio - Spectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology
8 University of Edinburgh
9 MPIB - Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry
10 Number 7 Science Park Road - National Institute of Biological Sciences [Beijing, China]
11 TU - Technical University of Berlin / Technische Universität Berlin
12 UNICAMP - Universidade Estadual de Campinas = University of Campinas
13 ISB - Institute for Systems Biology [Seattle]
14 UC Irvine - University of California [Irvine]
15 Kyoto University
16 University of Liverpool
17 HUJ - The Hebrew University of Jerusalem
18 University of Tübingen
19 Max Planck Institute for Developmental Biology
20 IMP - Research Institute of Molecular Pathology
21 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
22 Martin-Luther-University Halle-Wittenberg
23 University of Calgary
24 University of Leeds
25 UA - University of Antwerp
26 University of Konstanz
27 Birkbeck College [University of London]
28 UCL - University College of London [London]
29 Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen]
30 Thermo Fisher Scientific (Bremen) GmbH
31 EMBL-EBI - European Bioinformatics Institute [Hinxton]
32 UNSW - University of New South Wales [Sydney]
Juri Rappsilber
  • Function : Correspondent author
  • PersonId : 1087025

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Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.

Dates and versions

pasteur-03070494 , version 1 (15-12-2020)



Alexander Leitner, Alexandre Bonvin, Christoph Borchers, Robert Chalkley, Julia Chamot-Rooke, et al.. Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry. Structure, 2020, 28 (11), pp.1259-1268. ⟨10.1016/j.str.2020.09.011⟩. ⟨pasteur-03070494⟩
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