The replication machinery of LUCA: common origin of DNA replication and transcription - Institut Pasteur Access content directly
Journal Articles BMC Biology Year : 2020

The replication machinery of LUCA: common origin of DNA replication and transcription

Abstract

Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD.
Fichier principal
Vignette du fichier
Koonin2020BMCBiol.pdf (1.55 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

pasteur-02862286 , version 1 (09-06-2020)

Licence

Attribution

Identifiers

Cite

Eugene Koonin, Mart Krupovic, Sonoko Ishino, Yoshizumi Ishino. The replication machinery of LUCA: common origin of DNA replication and transcription. BMC Biology, 2020, 18 (1), pp.61. ⟨10.1186/s12915-020-00800-9⟩. ⟨pasteur-02862286⟩

Collections

PASTEUR ANR
58 View
117 Download

Altmetric

Share

Gmail Facebook X LinkedIn More