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Journal Articles Clinical Infectious Diseases Year : 2014

Prevention of Infections During Primary Immunodeficiency

Florence Moulin
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Odile Launay


Because infectious diseases are a major source of morbidity and mortality in the majority of patients with primary immunodeficiencies (PIDs), the application of a prophylactic regimen is often necessary. However, because of the variety of PIDs and pathogens involved, and because evidence is scarce, practices are heterogeneous. To homog-enize practices among centers, the French National Reference Center for PIDs aimed at elaborating recommendations for anti-infectious prophylaxis for the most common PIDs. We performed a literature review of infectious complications and prophylactic regimens associated with the most frequent PIDs. Then, a working group including different specialists systematically debated about chemoprophylaxis, immunotherapy, immunization, and recommendations for patients. Grading of prophylaxis was done using strength of recommendations (decreasing from A to D) and evidence level (decreasing from I to III). These might help infectious diseases specialists in the management of PIDs and improving the outcome of patients with PIDs.

Dates and versions

pasteur-02454019 , version 1 (24-01-2020)



Claire Aguilar, Marion Malphettes, Jean Donadieu, Olivia Chandesris, Hélène Coignard-Biehler, et al.. Prevention of Infections During Primary Immunodeficiency. Clinical Infectious Diseases, 2014, 59 (10), pp.1462-1470. ⟨10.1093/cid/ciu646⟩. ⟨pasteur-02454019⟩
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