%0 Journal Article %T Prevention of Infections During Primary Immunodeficiency %+ Centre d'infectiologie Necker-Pasteur [CHU Necker] %+ Centre de Référence Déficits Immunitaires Héréditaires (CEREDIH) %+ Service d'Immunopathologie [Hôpital Saint-Louis, Paris] %+ CHU Trousseau [APHP] %+ Imagine - Institut des maladies génétiques (IMAGINE - U1163) %+ Hôpital Foch [Suresnes] %+ Centre Hospitalier Universitaire d'Angers (CHU Angers) %+ Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E) %+ Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France %+ Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM] %+ CHU Necker - Enfants Malades [AP-HP] %+ CHU Dupuytren %+ CIC Cochin Pasteur (CIC 1417) %+ Service des Maladies infectieuses et tropicales [CHU Necker] %+ Université Paris Descartes - Paris 5 (UPD5) %+ Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163) %+ Hôpital Saint-Louis %+ Service d'immuno-hématologie pédiatrique [CHU Necker] %+ Collège de France - Chaire Médecine expérimentale (A. Fischer) %A Aguilar, Claire %A Malphettes, Marion %A Donadieu, Jean %A Chandesris, Olivia %A Coignard-Biehler, Hélène %A Catherinot, Emilie %A Pellier, Isabelle %A Stéphan, Jean-Louis %A Le Moing, Vincent %A Barlogis, Vincent %A Suarez, Felipe %A Gérart, Stéphane %A Lanternier, Fanny %A Jaccard, Arnaud %A Consigny, Paul-Henri %A Moulin, Florence %A Launay, Odile %A Lecuit, Marc %A Hermine, Olivier %A Oksenhendler, Eric %A Picard, Capucine %A Blanche, Stéphane %A Fischer, Alain %A Mahlaoui, Nizar %A Lortholary, Olivier %< avec comité de lecture %@ 1058-4838 %J Clinical Infectious Diseases %I Oxford University Press (OUP) %V 59 %N 10 %P 1462-1470 %8 2014-11-15 %D 2014 %R 10.1093/cid/ciu646 %M 25124061 %K prophylaxis %K primary immunodeficiency %K immunoglobulins %K immunizations %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Human health and pathology %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseases %Z Life Sciences [q-bio]/ImmunologyJournal articles %X Because infectious diseases are a major source of morbidity and mortality in the majority of patients with primary immunodeficiencies (PIDs), the application of a prophylactic regimen is often necessary. However, because of the variety of PIDs and pathogens involved, and because evidence is scarce, practices are heterogeneous. To homog-enize practices among centers, the French National Reference Center for PIDs aimed at elaborating recommendations for anti-infectious prophylaxis for the most common PIDs. We performed a literature review of infectious complications and prophylactic regimens associated with the most frequent PIDs. Then, a working group including different specialists systematically debated about chemoprophylaxis, immunotherapy, immunization, and recommendations for patients. Grading of prophylaxis was done using strength of recommendations (decreasing from A to D) and evidence level (decreasing from I to III). These might help infectious diseases specialists in the management of PIDs and improving the outcome of patients with PIDs. %G English %Z The authors thank Janet Jacobson for excellent editing of the manuscript. %L pasteur-02454019 %U https://pasteur.hal.science/pasteur-02454019 %~ PASTEUR %~ UNIV-PARIS5 %~ UNIV-PARIS7 %~ UNIV-AMU %~ CDF %~ APHP %~ UNAM %~ PSL %~ CHU-UNIV-PARIS5 %~ SORBONNE-UNIVERSITE %~ SU-INF-2018 %~ SU-MEDECINE %~ SU-MED %~ UNIV-PARIS %~ UP-SANTE %~ CDF-PSL %~ SU-TI %~ ALLIANCE-SU %~ CIC1417