Pathogens, microbiome and the host: emergence of the ecological Koch's postulates - Institut Pasteur Access content directly
Journal Articles FEMS Microbiology Reviews Year : 2018

Pathogens, microbiome and the host: emergence of the ecological Koch's postulates

Abstract

Even though tremendous progress has been made in the last decades to elucidate the mechanisms of intestinal homeostasis, dysbiosis and disease, we are only at the beginning of understanding the complexity of the gut ecosystem and the underlying interaction networks. We are also only starting to unravel the mechanisms that pathogens have evolved to overcome the barriers imposed by the microbiota and host to exploit the system to their own benefit. Recent work in these domains clearly indicates that the 'traditional Koch's postulates', which state that a given pathogen leads to a distinct disease, are not valid for all 'infectious' diseases, but that a more complete and complex interpretation of Koch's postulates is needed in order to understand and explain them. This review summarises the current understanding of what defines a healthy gut ecosystem and highlights recent progress in uncovering the interplay between the host, its microbiota and invading intestinal pathogens. Based on these recent findings, we propose a new interpretation of Koch's postulates that we term 'ecological Koch's postulates'.
Fichier principal
Vignette du fichier
VonaeschetalFEMSReview2018.pdf (2.63 Mo) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

pasteur-02305645 , version 1 (04-10-2019)

Licence

Identifiers

Cite

Pascale Vonaesch, Mark Anderson, Philippe Sansonetti. Pathogens, microbiome and the host: emergence of the ecological Koch's postulates. FEMS Microbiology Reviews, 2018, 42 (3), pp.273-292. ⟨10.1093/femsre/fuy003⟩. ⟨pasteur-02305645⟩
501 View
600 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More