Gene flow contributes to diversification of the major fungal pathogen $Candida\ albicans$ - Institut Pasteur Access content directly
Journal Articles Nature Communications Year : 2018

Gene flow contributes to diversification of the major fungal pathogen $Candida\ albicans$

Christophe Battail
Jong Hee Shin
  • Function : Author
  • PersonId : 1007633

Abstract

Elucidating population structure and levels of genetic diversity and recombination is necessary to understand the evolution and adaptation of species. $Candida\ albicans$ is the second most frequent agent of human fungal infections worldwide, causing high-mortality rates. Here we present the genomic sequences of 182 C. $albicans$ isolates collected worldwide, including commensal isolates, as well as ones responsible for superficial and invasive infections, constituting the largest dataset to date for this major fungal pathogen. Although, C. $albicans$ shows a predominantly clonal population structure, we find evidence of gene flow between previously known and newly identified genetic clusters, supporting the occurrence of (para)sexuality in nature. A highly clonal lineage, which experimentally shows reduced fitness, has undergone pseudogenization in genes required for virulence and morphogenesis, which may explain its niche restriction. $Candida\ albicans$ thus takes advantage of both clonality and gene flow to diversify.
Fichier principal
Vignette du fichier
s41467-018-04787-4.pdf (2.89 Mo) Télécharger le fichier
Origin Publication funded by an institution
Loading...

Dates and versions

pasteur-01815656 , version 1 (14-06-2018)

Licence

Identifiers

Cite

Jeanne Ropars, Corinne Maufrais, Dorothée Diogo, Marina Marcet-Houben, Aurélie Perin, et al.. Gene flow contributes to diversification of the major fungal pathogen $Candida\ albicans$. Nature Communications, 2018, 9 (1), pp.2253. ⟨10.1038/s41467-018-04787-4⟩. ⟨pasteur-01815656⟩
1825 View
135 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More