Diverted recycling— Shigella subversion of Rabs - Institut Pasteur Access content directly
Journal Articles Small GTPases Year : 2018

Diverted recycling— Shigella subversion of Rabs


Small GTPases of the Rab protein family control intracellular vesicular trafficking to allow their communication and maintenance. It is a common strategy for intracellular bacteria to exploit these pathways to shape their respective niches for survival. The subversion of Rabs for the generation of an intracellular environment favoring the pathogen has been described almost exclusively for intracellular bacteria that reside within bacterial containing vacuoles (BCVs). However, less is known about Rab subversion for bacteria that rupture the BCV to reach the host cytoplasm. Here, we provide recent examples of Rab targeting by both groups of intracellular bacteria with a special focus on Shigella, the causative agent of bacillary dysentery. Shigella recruits Rab11, the hallmark of the perinuclear recycling compartment to in situ formed macropinosomes at the entry foci via the bacterial effector IpgD. This leads to efficient BCV rupture and cytosolic escape. We discuss the concept of diverted recycling through host Rab GTPases that emerges as a novel pathogen strategy.
Fichier principal
Vignette du fichier
Diverted recycling- Shigella subversion of Rabs 2016.pdf (1.17 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-01388795 , version 1 (27-10-2016)





Noelia López-Montero, Jost Enninga. Diverted recycling— Shigella subversion of Rabs. Small GTPases, 2018, 9 (5), pp.365-374. ⟨10.1080/21541248.2016.1240494⟩. ⟨pasteur-01388795⟩
160 View
137 Download



Gmail Facebook X LinkedIn More