A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides. - Institut Pasteur Access content directly
Journal Articles Journal of Organic Chemistry Year : 2003

A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides.

Abstract

The synthesis of fully [13C/15N] labeled pyrimidine nucleosides has been achieved from 13C-glucose and labeled nucleobases. The reaction scheme leads directly to the protected nucleosides without the need for the inversion of configuration of C-3 of 13C-glucose. This was achieved by an oxitative ring-opening reaction removing the carbon with the wrong configuration.

Dates and versions

pasteur-00166200 , version 1 (01-08-2007)

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Irene M Lagoja, Sylvie Pochet, Valerie Boudou, Roy Little, Eveline Lescrinier, et al.. A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides.. Journal of Organic Chemistry, 2003, 68 (5), pp.1867-71. ⟨10.1021/jo0205098⟩. ⟨pasteur-00166200⟩

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