The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Immunity Année : 2024

The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies

Résumé

Aicardi-Goutières syndrome (AGS) is an autoinflammatory disease characterized by aberrant interferon (IFN)-α production. The major cause of morbidity in AGS is brain disease, yet the primary source and target of neurotoxic IFN-α remain unclear. Here, we demonstrated that the brain was the primary source of neurotoxic IFN-α in AGS and confirmed the neurotoxicity of intracerebral IFN-α using astrocyte-driven Ifna1 misexpression in mice. Using single-cell RNA sequencing, we demonstrated that intracerebral IFN-α-activated receptor (IFNAR) signaling within cerebral endothelial cells caused a distinctive cerebral small vessel disease similar to that observed in individuals with AGS. Magnetic resonance imaging (MRI) and single-molecule ELISA revealed that central and not peripheral IFN-α was the primary determinant of microvascular disease in humans. Ablation of endothelial Ifnar1 in mice rescued microvascular disease, stopped the development of diffuse brain disease, and prolonged lifespan. These results identify the cerebral microvasculature as a primary mediator of IFN-α neurotoxicity in AGS, representing an accessible target for therapeutic intervention.
Fichier principal
Vignette du fichier
1-s2.0-S1074761324002711-main.pdf (7.56 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

pasteur-04646140 , version 1 (12-07-2024)

Licence

Identifiants

Citer

Barney Viengkhou, Emina Hayashida, Sarah Mcglasson, Katie Emelianova, Deborah Forbes, et al.. The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies. Immunity, 2024, 57 (7), pp.1696-1709.e10. ⟨10.1016/j.immuni.2024.05.017⟩. ⟨pasteur-04646140⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More