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Article Dans Une Revue Journal of Virology Année : 2024

Ambiviricota , a novel ribovirian phylum for viruses with viroid-like properties

Résumé

Fungi harbor a vast diversity of mobile genetic elements (MGEs). Recently, novel fungal MGEs, tentatively referred to as ‘ambiviruses,’ were described. ‘Ambiviruses’ have single-stranded RNA genomes of about 4–5 kb in length that contain at least two open reading frames (ORFs) in non-overlapping ambisense orientation. Both ORFs are conserved among all currently known ‘ambiviruses,’ and one of them encodes a distinct viral RNA-directed RNA polymerase (RdRP), the hallmark gene of ribovirian kingdom Orthornavirae . However, ‘ambivirus’ genomes are circular and predicted to replicate via a rolling-circle mechanism. Their genomes are also predicted to form rod-like structures and contain ribozymes in various combinations in both sense and antisense orientations—features reminiscent of viroids, virusoids, ribozyvirian kolmiovirids, and yet-unclassified MGEs (such as ‘epsilonviruses,’ ‘zetaviruses,’ and some ‘obelisks’). As a first step toward the formal classification of ‘ambiviruses,’ the International Committee on Taxonomy of Viruses (ICTV) recently approved the establishment of a novel ribovirian phylum, Ambiviricota , to accommodate an initial set of 20 members with well-annotated genome sequences.
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pasteur-04613279 , version 1 (16-06-2024)

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Jens H Kuhn, Leticia Botella, Marcos de la Peña, Eeva J Vainio, Mart Krupovic, et al.. Ambiviricota , a novel ribovirian phylum for viruses with viroid-like properties. Journal of Virology, In press, ⟨10.1128/jvi.00831-24⟩. ⟨pasteur-04613279⟩

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