Article Dans Une Revue Frontiers in Microbiology Année : 2023

Lipid A structural diversity among members of the genus Leptospira

Résumé

Lipid A is the hydrophobic component of bacterial lipopolysaccharide and an activator of the host immune system. Bacteria modify their lipid A structure to adapt to the surrounding environment and, in some cases, to evade recognition by host immune cells. In this study, lipid A structural diversity within the Leptospira genus was explored. The individual Leptospira species have dramatically different pathogenic potential that ranges from non-infectious to life-threatening disease (leptospirosis). Ten distinct lipid A profiles, denoted L1-L10, were discovered across 31 Leptospira reference species, laying a foundation for lipid A-based molecular typing. Tandem MS analysis revealed structural features of Leptospira membrane lipids that might alter recognition of its lipid A by the host innate immune receptors. Results of this study will aid development of strategies to improve diagnosis and surveillance of leptospirosis, as well as guide functional studies on Leptospira lipid A activity.
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pasteur-04607784 , version 1 (11-06-2024)

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Helena Pětrošová, Abanoub Mikhael, Sophie Culos, Alexandre Giraud-Gatineau, Alloysius M Gomez, et al.. Lipid A structural diversity among members of the genus Leptospira. Frontiers in Microbiology, 2023, 14, pp.1181034. ⟨10.3389/fmicb.2023.1181034⟩. ⟨pasteur-04607784⟩

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