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Article Dans Une Revue Microorganisms Année : 2023

Concealed for a Long Time on the Marches of Empires: Hepatitis B Virus Genotype I

Résumé

Genotype I, the penultimate HBV genotype to date, was granted the status of a bona fide genotype only in the XXIst century after some hesitations. The reason for these hesitations was that genotype I is a complex recombinant virus formed with segments from three original genotypes, A, C, and G. It was estimated that genotype I is responsible for only an infinitesimal fraction (<1.0%) of the chronic HBV infection burden worldwide. Furthermore, most probably due to its recent discovery and rarity, the natural history of infection with genotype I is poorly known in comparison with those of genotypes B or C that predominate in their area of circulation. Overall, genotype I is a minor genotype infecting ethnic minorities. It is endemic to the Southeast Asian Massif or Eastern Zomia, a vast mountainous or hilly region of 2.5 million km2 spreading from Eastern India to China, inhabited by a little more than 100 million persons belonging primarily to ethnic minorities speaking various types of languages (Tibeto-Burman, Austroasiatic, and Tai-Kadai) who managed to escape the authority of central states during historical times. Genotype I consists of two subtypes: I1, present in China, Laos, Thailand, and Vietnam; and I2, encountered in India, Laos, and Vietnam.
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Licence : CC BY - Paternité

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pasteur-04206729 , version 1 (14-09-2023)

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Agnès Marchio, Philavanh Sitbounlang, Eric Deharo, Phimpha Paboriboune, Pascal Pineau. Concealed for a Long Time on the Marches of Empires: Hepatitis B Virus Genotype I. Microorganisms, 2023, 11 (9), pp.2204. ⟨10.3390/microorganisms11092204⟩. ⟨pasteur-04206729⟩
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