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Article Dans Une Revue iScience Année : 2023

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics

Résumé

T cells become activated following one or multiple contacts with antigen-presenting cells. Calcium influx is a key signaling event elicited during these cellular interactions; however, it is unclear whether T cells recall and integrate calcium signals elicited during temporally separated contacts. To study the integration of calcium signals, we designed a programmable, multiplex illumination strategy for temporally patterned optogenetics (TEMPO). We found that a single round of calcium elevation was insufficient to promote nuclear factor of activated T cells (NFAT) activity and cytokine production in a T cell line. However, robust responses were detected after a second identical stimulation even when signals were separated by several hours. Our results suggest the existence of a biochemical memory of calcium signals in T cells that favors signal integration during temporally separated contacts and promote cytokine production. As illustrated here, TEMPO is a versatile approach for dissecting temporal integration in defined signaling pathways.
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pasteur-04158318 , version 1 (11-07-2023)

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Béatrice Corre, Yassine El Janati Elidrissi, Justine Duval, Mailys Quilhot, Gaëtan Lefebvre, et al.. Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics. iScience, 2023, 26 (2), pp.106068. ⟨10.1016/j.isci.2023.106068⟩. ⟨pasteur-04158318⟩

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