Article Dans Une Revue mBio Année : 2023

Bacterial Type II Secretion System and Its Mitochondrial Counterpart

Résumé

Over the billions of years that bacteria have been around, they have evolved several sophisticated protein secretion nanomachines to deliver toxins, hydrolytic enzymes, and effector proteins into their environments. Of these, the type II secretion system (T2SS) is used by Gram-negative bacteria to export a wide range of folded proteins from the periplasm across the outer membrane. Recent findings have demonstrated that components of the T2SS are localized in mitochondria of some eukaryotic lineages, and their behavior is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS). This review focuses on recent advances in the field and discusses open questions concerning the function and evolution of miT2SSs.
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pasteur-04121470 , version 1 (07-06-2023)

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Anna Shaliutina-Loginova, Olivera Francetic, Pavel Doležal. Bacterial Type II Secretion System and Its Mitochondrial Counterpart. mBio, 2023, 14 (2), ⟨10.1128/mbio.03145-22⟩. ⟨pasteur-04121470⟩

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