Reconstructing long-term dengue virus immunity in French Polynesia - Institut Pasteur Access content directly
Journal Articles PLoS Neglected Tropical Diseases Year : 2022

Reconstructing long-term dengue virus immunity in French Polynesia

Abstract

Background Understanding the underlying risk of infection by dengue virus from surveillance systems is complicated due to the complex nature of the disease. In particular, the probability of becoming severely sick is driven by serotype-specific infection histories as well as age; however, this has rarely been quantified. Island communities that have periodic outbreaks dominated by single serotypes provide an opportunity to disentangle the competing role of serotype, age and changes in surveillance systems in characterising disease risk. Methodology We develop mathematical models to analyse 35 years of dengue surveillance (1979–2014) and seroprevalence studies from French Polynesia. We estimate the annual force of infection, serotype-specific reporting probabilities and changes in surveillance capabilities using the annual age and serotype-specific distribution of dengue. Principal findings Eight dengue epidemics occurred between 1979 and 2014, with reporting probabilities for DENV-1 primary infections increasing from 3% to 5%. The reporting probability for DENV-1 secondary infections was 3.6 times that for primary infections. We also observed heterogeneity in reporting probabilities by serotype, with DENV-3 having the highest probability of being detected. Reporting probabilities declined with age after 14 y.o. Between 1979 and 2014, the proportion never infected declined from 70% to 23% while the proportion infected at least twice increased from 4.5% to 45%. By 2014, almost half of the population had acquired heterotypic immunity. The probability of an epidemic increased sharply with the estimated fraction of susceptibles among children. Conclusion/Significance By analysing 35 years of dengue data in French Polynesia, we characterised key factors affecting the dissemination profile and reporting of dengue cases in an epidemiological context simplified by mono-serotypic circulation. Our analysis provides key estimates that can inform the study of dengue in more complex settings where the co-circulation of multiple serotypes can greatly complicate inference.
Fichier principal
Vignette du fichier
Nemoto et al. PNTD 2022.pdf (1.99 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Licence : CC BY - Attribution

Dates and versions

pasteur-04009100 , version 1 (01-03-2023)

Licence

Attribution

Identifiers

Cite

Takahiro Nemoto, Maite Aubry, Yoann Teissier, Richard E. Paul, Van-Mai Cao-Lormeau, et al.. Reconstructing long-term dengue virus immunity in French Polynesia. PLoS Neglected Tropical Diseases, 2022, 16 (10), pp.e0010367. ⟨10.1371/journal.pntd.0010367⟩. ⟨pasteur-04009100⟩
8 View
20 Download

Altmetric

Share

Gmail Facebook X LinkedIn More