Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination - Institut Pasteur Access content directly
Journal Articles (Data Paper) Proceedings of the National Academy of Sciences of the United States of America Year : 2023

Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination

Abstract

Peptidoglycan, the major structural polymer forming the cell wall of bacteria, is an important mediator of physiological and behavioral effects in mammalian hosts. These effects are frequently linked to its translocation from the intestinal lumen to host tissues. However, the modality and regulation of this translocation across the gut barrier has not been precisely addressed. In this study, we characterized the absorption of peptidoglycan across the intestine and its systemic dissemination. We report that peptidoglycan has a distinct tropism for host organs when absorbed via the gut, most notably by favoring access to the brain. We demonstrate that intestinal translocation of peptidoglycan occurs through a microbiota-induced active process. This process is regulated by the parasympathetic pathway via the muscarinic acetylcholine receptors. Together, this study reveals fundamental parameters concerning the uptake of a major microbiota molecular signal from the steady-state gut.
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Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives

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pasteur-03995078 , version 1 (17-02-2023)

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Attribution - NonCommercial - NoDerivatives

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Richard Wheeler, Paulo André Dias Bastos, Olivier Disson, Aline Rifflet, Ilana Gabanyi, et al.. Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (4), pp.e2209936120. ⟨10.1073/pnas.2209936120⟩. ⟨pasteur-03995078⟩
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