Cadherins in the Auditory Sensory Organ - Institut Pasteur Access content directly
Book Sections Year : 2016

Cadherins in the Auditory Sensory Organ


The exquisite sensitivity and frequency tuning of hearing depend on the correct structure and functioning of the auditory sensory hair cells, the neighbouring supporting cells, and the homeostasis of their ionic environment. The increasing number of adhesion proteins identified as causing hearing impairment in humans and mice when defective is consistent with a critical role for cellcell junctions between neighbouring epithelial cells of the cochlea, and of fibrous links within the hair bundle, the sensory hair cell structure responsible for sound reception. Classical cadherins and/or associated adherens-junction proteins, such as p120-catenin or nectin 3, have been shown to be essential for establishment of the regular mosaic cellular pattern of the auditory sensory epithelium. Two cadherinrelated proteins, protocadherin-15 and cadherin-23, are key components of both lateral links and tip-links in hair bundles; they are essential components of the mechanoelectrical transduction machinery. Studies of the role of these adhesion proteins and of the pathogenesis of the forms of deafness caused by defects of these proteins have provided considerable insight into the development and functioning of the auditory sensory epithelium, and of the hair cells in particular.
No file

Dates and versions

pasteur-03922347 , version 1 (04-01-2023)



Aziz El-Amraoui, Christine Petit. Cadherins in the Auditory Sensory Organ. Suzuki, S; Hirano, S. The Cadherin Superfamily, Springer, pp.341 - 361, 2016, 978-4-431-56033-3. ⟨10.1007/978-4-431-56033-3_13⟩. ⟨pasteur-03922347⟩
7 View
1 Download



Gmail Facebook Twitter LinkedIn More