Circovirus hepatitis infection in heart-lung transplant patient, France - Institut Pasteur Access content directly
Journal Articles Emerging Infectious Diseases Year : 2023

Circovirus hepatitis infection in heart-lung transplant patient, France

Hélène Fontaine
  • Function : Author
  • PersonId : 1164353
Agnès Ferroni
  • Function : Author
  • PersonId : 902518
Anne Jamet

Abstract

In March 2022, a 61-year-old woman in France who had received a heart-lung transplant sought treatment with chronic hepatitis mainly characterized by increased liver enzymes. After ruling out common etiologies, we used metagenomic next-generation sequencing to analyze a liver biopsy sample and identified an unknown species of circovirus, tentatively named human circovirus 1 (HCirV-1). We found no other viral or bacterial sequences. HCirV-1 shared 70% amino acid identity with the closest known viral sequences. The viral genome was undetectable in blood samples from 2017–2019, then became detectable at low levels in September 2020 and peaked at very high titers (10^10 genome copies/mL) in January 2022. In March 2022, we found >10^8 genome copies/g or mL in the liver and blood, concomitant with hepatic cytolysis. We detected HCirV-1 transcripts in 2% of hepatocytes, demonstrating viral replication and supporting the role of HCirV-1 in liver damage.
Fichier principal
Vignette du fichier
22-1468.pdf (2.54 Mo) Télécharger le fichier
Origin Publication funded by an institution
Licence

Dates and versions

pasteur-03921721 , version 1 (28-03-2023)

Licence

Identifiers

Cite

Philippe Pérot, Jacques Fourgeaud, Claire Rouzaud, Béatrice Regnault, Nicolas da Rocha, et al.. Circovirus hepatitis infection in heart-lung transplant patient, France. Emerging Infectious Diseases, 2023, 29 (2), ⟨10.3201/eid2902.221468⟩. ⟨pasteur-03921721⟩
102 View
35 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More