Degradation of Exogenous Fatty Acids in Escherichia coli
Résumé
Many bacteria possess all the machineries required to grow on fatty acids (FA) as a unique
source of carbon and energy. FA degradation proceeds through the -oxidation cycle that produces
acetyl-CoA and reduced NADH and FADH cofactors. In addition to all the enzymes required for
-oxidation, FA degradation also depends on sophisticated systems for its genetic regulation and
for FA transport. The fact that these machineries are conserved in bacteria suggests a crucial role
in environmental conditions, especially for enterobacteria. Bacteria also possess specific enzymes
required for the degradation of FAs from their environment, again showing the importance of
this metabolism for bacterial adaptation. In this review, we mainly describe FA degradation in
the Escherichia coli model, and along the way, we highlight and discuss important aspects of this
metabolism that are still unclear. We do not detail exhaustively the diversity of the machineries found
in other bacteria, but we mention them if they bring additional information or enlightenment on
specific aspects.
Domaines
BactériologieOrigine | Publication financée par une institution |
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