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Journal Articles FEMS Microbiology Letters Year : 2021

Going to extremes – a metagenomic journey into the dark matter of life

Arnthór Aevarsson (1) , Anna-Karina Kaczorowska (2) , Björn Thor Adalsteinsson (1) , Josefin Ahlqvist (3) , Salam Al-Karadaghi (4) , Joseph Altenbuchner (5) , Hasan Arsin (6) , Úlfur Áugúst Átlasson (1) , David Brandt (7) , Magdalena Cichowicz-Cieślak (2) , Katy A. S. Cornish (8) , Jérémy Courtin (1) , Slawomir Dabrowski (9) , Håkon Dahle (6) , Samia Djeffane (1) , Sebastian Dorawa (2) , Julia Dusaucy (1) , Francois Enault (10) , Anita-Elin Fedøy (6) , Stefanie Freitag-Pohl (8) , Olafur H Fridjonsson (1) , Clovis Galiez (11) , Eirin Glomsaker (12) , Mickael Guérin (1) , Sigurd E. Gundesø (12) , Elisabet E. Gudmundsdóttir (1) , Hördur Gudmundsson (1) , Maria Håkansson (4) , Christian Henke (7) , Alexandra Helleux (1) , Jørn Remi Henriksen (12) , Sigrídur Hjörleifdóttir (1) , Gudmundur O. Hreggvidsson (1, 13) , Andrius Jasilionis (3) , Annika Jochheim (11) , Ilmur Jónsdóttir (1) , Lilja Björk Jónsdóttir (1) , Agata Jurczak-Kurek (2) , Tadeusz Kaczorowski (2) , Jörn Kalinowski (7) , Lukasz P. Kozlowski (11, 14) , Mart Krupovic (15) , Karolina Kwiatkowska-Semrau (2) , Olav Lanes (12) , Joanna Lange (16) , Julien Lebrat (1) , Javier Linares-Pastén (3) , Ying Liu (15) , Steffen A. Lorentsen (12) , Tobias Lutterman (7) , Thibaud Mas (10) , William Merré (1) , Milot Mirdita (11) , Agnieszka Morzywołek (2) , Eric Olo Ndela (10) , Eva Nordberg Karlsson (3) , Edda Olgudóttir (1) , Cathrine Pedersen (12) , Francine Perler (17) , Sólveig K. Pétursdóttir (1) , Magdalena Plotka (2) , Ehmke Pohl (8) , David Prangishvili (15) , Jessica L. Ray (6, 18) , Birkir Reynisson (1) , Tara Róbertsdóttir (1) , Ruth-Anne Sandaa (6) , Alexander Sczyrba (7) , Sigurlaug Skírnisdóttir (1) , Johannes Söding (11) , Terese Solstad (12) , Ida H. Steen (6) , Sigmar Karl Stefánsson (1) , Martin Steinegger (11) , Katrine Stange Overå (12) , Bernd Striberny (12) , Anders Svensson (4) , Monika Szadkowska (2) , Emma J. Tarrant (8) , Paul Terzian (10) , Mathilde Tourigny (1) , Tom van den Bergh (16) , Justine Vanhalst (1) , Jonathan Vincent (10) , Bas Vroling (16) , Björn Walse (4) , Lei Wang (19) , Hildegard Watzlawick (19) , Martin Welin (4) , Olesia Werbowy (2) , Ewa Wons (2) , Ruoshi Zhang (11)
Björn Thor Adalsteinsson
Hasan Arsin
  • Function : Author
Tadeusz Kaczorowski
Ehmke Pohl
  • Function : Author
Lei Wang
  • Function : Author
Ewa Wons
  • Function : Author

Abstract

The Virus-X—Viral Metagenomics for Innovation Value—project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.

Dates and versions

pasteur-03698255 , version 1 (17-06-2022)

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Arnthór Aevarsson, Anna-Karina Kaczorowska, Björn Thor Adalsteinsson, Josefin Ahlqvist, Salam Al-Karadaghi, et al.. Going to extremes – a metagenomic journey into the dark matter of life. FEMS Microbiology Letters, 2021, 368 (12), pp.fnab067. ⟨10.1093/femsle/fnab067⟩. ⟨pasteur-03698255⟩
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