Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment - Institut Pasteur Access content directly
Journal Articles PLoS Pathogens Year : 2020

Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment

Ben Killingley
  • Function : Correspondent author
  • PersonId : 1108370

Connectez-vous pour contacter l'auteur
Anthony Gilbert
  • Function : Author
Alexander Mann
  • Function : Author
John Forni
  • Function : Author
The Emit Consortium
  • Function : Author

Abstract

Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowledge gap. Healthy, seronegative volunteer 'Donors' (n = 52) were randomly selected for intranasal challenge with influenza A/Wisconsin/67/2005 (H3N2). 'Recipients' randomized to Intervention (IR, n = 40) or Control (CR, n = 35) groups were exposed to Donors for four days. IRs wore face shields and hand sanitized frequently to limit large droplet and contact transmission. One transmitted infection was confirmed by serology in a CR, yielding a secondary attack rate of 2.9% among CR, 0% in IR (p = 0.47 for group difference), and 1.3% overall, significantly less than 16% (p<0.001) expected based on a proof-of-concept study secondary attack rate and considering that there were twice as many Donors and days of exposure. The main difference between these studies was mechanical building ventilation in the follow-on study, suggesting a possible role for aerosols.
Fichier principal
Vignette du fichier
ppat.1008704.pdf (1.52 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03325916 , version 1 (25-08-2021)

Licence

CC0 - Public Domain Dedication

Identifiers

Cite

Jonathan Nguyen-Van-Tam, Ben Killingley, Joanne Enstone, Michael Hewitt, Jovan Pantelic, et al.. Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment. PLoS Pathogens, 2020, 16 (7), pp.e1008704. ⟨10.1371/journal.ppat.1008704⟩. ⟨pasteur-03325916⟩
7 View
21 Download

Altmetric

Share

Gmail Facebook X LinkedIn More