A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma - Institut Pasteur Access content directly
Journal Articles Nature Year : 1987

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

Abstract

We have previously isolated from a human hepatocellular carcinoma a hepatitis B virus integration in a 147-base-pair cellular DNA fragment, similar to steroid- and c-erb-A/thyroid-hormone receptor genes. We have now cloned the corresponding complementary DNA from a human-liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which we have named hap, is similar to that of the DNA-binding hormone receptors. That is, it displays two highly conserved regions identified as the putative DNA-binding and hormone-binding domains of the c-erb A/steroid receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5-kilobase (kb) hap messenger RNA species which is undetectable in normal adult and fetal livers but present in all non-hepatic tissues analysed. The data suggest that the hap gene product may be a novel ligand-responsive regulatory protein whose inappropriate expression in liver may relate to the hepatocellular carcinogenesis.

Dates and versions

pasteur-03238341 , version 1 (27-05-2021)

Identifiers

Cite

Hugues de Thé, Agnès Marchio, Pierre Tiollais, Anne Dejean. A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature, 1987, 330 (6149), pp.667-670. ⟨10.1038/330667a0⟩. ⟨pasteur-03238341⟩
20 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More