MicroRNAs and lncRNAs in senescence: A re‐view - Institut Pasteur Access content directly
Journal Articles IUBMB Life Year : 2015

MicroRNAs and lncRNAs in senescence: A re‐view


Cellular senescence is a stress response to a variety of extrinsic and intrinsic insults that cause genomic or epigenomic perturbations. It is now widely recognized as a potent tumor suppressor mechanism as well as a biological process impacting aging and organismal development. Like other cell fate decisions, senescence is executed and maintained by an intricate network of transcription factors (TFs), chromatin modifiers, and noncoding RNAs (ncRNAs). Altogether, these factors cooperate to implement the gene expression program that initiates and sustains the senescent phenotype. In the context of senescence, microRNAs (miRs) and long ncRNAs have been found to play regulatory roles at both the transcriptional and post-transcriptional levels. In this review, we discuss recent developments in the field and point toward future research directions to gain a better understanding of ncRNAs in senescence.
Fichier principal
Vignette du fichier
iub.1373.pdf (1.24 Mo) Télécharger le fichier

Dates and versions

pasteur-03234975 , version 1 (25-05-2021)




Oliver Bischof, Ricardo Iván Martínez-Zamudio. MicroRNAs and lncRNAs in senescence: A re‐view. IUBMB Life, 2015, 67 (4), pp.255-267. ⟨10.1002/iub.1373⟩. ⟨pasteur-03234975⟩


96 View
102 Download



Gmail Mastodon Facebook X LinkedIn More