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Journal Articles PLoS Computational Biology Year : 2021

SARS-CoV-2 viral dynamics in non-human primates

Caroline Solas
Franck Touret
Xavier de Lamballerie


Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>10 4 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
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Dates and versions

pasteur-03207908 , version 1 (26-04-2021)





Antonio Gonçalves, Pauline Maisonnasse, Flora Donati, Mélanie Albert, Sylvie Behillil, et al.. SARS-CoV-2 viral dynamics in non-human primates. PLoS Computational Biology, 2021, 17 (3), pp.e1008785. ⟨10.1371/journal.pcbi.1008785⟩. ⟨pasteur-03207908⟩
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