Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice - Institut Pasteur Access content directly
Journal Articles Experimental Parasitology Year : 2008

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice

Abstract

Protozoan parasites of the genus Leishmania escape from the immune response by interfering with signal transduction pathways of its host cell, the macrophage, thereby establishing permissive conditions for intracellular survival. Inhibition of macrophage activation after Leishmania infection has been suggested to require activation of the host cell phosphatase SHP-1. However, by utilizing infections of SHP-1 deficient (me(v)) and CD45 null mutant mice or macrophages, we provide evidence that intracellular survival of Leishmania major is not generally dependent on these cellular phosphatases.

Dates and versions

pasteur-03109079 , version 1 (13-01-2021)

Identifiers

Cite

Gerald F Späth, Mary Ann Mcdowell, Stephen Beverley. Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice. Experimental Parasitology, 2008, 120 (3), pp.275-279. ⟨10.1016/j.exppara.2008.07.003⟩. ⟨pasteur-03109079⟩

Collections

PASTEUR CNRS
28 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More