Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects - Institut Pasteur Access content directly
Journal Articles Cell Reports Year : 2020

Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects


Transgenerational immune priming (TGIP) allows memory-like immune responses to be transmitted from parents to offspring in many invertebrates. Despite increasing evidence for TGIP in insects, the mechanisms involved in the transfer of information remain largely unknown. Here, we show that Drosophila melanogaster and Aedes aegypti transmit antiviral immunological memory to their progeny that lasts throughout generations. We observe that TGIP, which is virus and sequence specific but RNAi independent, is initiated by a single exposure to disparate RNA viruses and also by inoculation of a fragment of viral double-stranded RNA. The progeny, which inherit a viral DNA that is only a fragment of the viral RNA used to infect the parents, display enriched expression of genes related to chromatin and DNA binding. These findings represent a demonstration of TGIP for RNA viruses in invertebrates, broadly increasing our understanding of the immune response, host genome plasticity, and antiviral memory of the germline.
Fichier principal
Vignette du fichier
Evidence for long lasting.pdf (3.07 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03094024 , version 1 (04-01-2021)


Attribution - NonCommercial - NoDerivatives



Juan A Mondotte, Valérie Gausson, Lionel Frangeul, Yasutsugu Suzuki, Marie Vazeille, et al.. Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects. Cell Reports, 2020, 33 (11), pp.108506. ⟨10.1016/j.celrep.2020.108506⟩. ⟨pasteur-03094024⟩
83 View
66 Download



Gmail Facebook X LinkedIn More