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Journal Articles Journal of Antimicrobial Chemotherapy Year : 2000

Retrospective screening for heterogeneous vancomycin resistance in diverse Staphylococcus aureus clones disseminated in French hospitals

Abstract

Twenty-five different Staphylococcus aureus strains that are widespread in France were screened by various methods for heterogeneous and low-level resistance to vancomycin. Population analysis on brain-heart infusion agar containing 4 mg/L of the drug detected resistant cells at frequencies of 10-7 to 10-6 in five multiply resistant strains. There was no antagonism between vancomycin and beta-lactam antibiotics. One of the five strains, isolated in 1993, was considered a putative progenitor of a French nosocomial S. aureus strain isolated in 1998 and for which the vancomycin MIC was 8 mg/L.

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Bacteriology

Dates and versions

pasteur-03082468 , version 1 (18-12-2020)

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Olivier Chesneau, A. Morvan, N. Solh. Retrospective screening for heterogeneous vancomycin resistance in diverse Staphylococcus aureus clones disseminated in French hospitals. Journal of Antimicrobial Chemotherapy, 2000, 45 (6), pp.887-890. ⟨10.1093/jac/45.6.887⟩. ⟨pasteur-03082468⟩

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