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Journal Articles Genes and Immunity Year : 2020

Host genetic susceptibility to viral infections: the role of type I interferon induction

Abstract

The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, which trigger a cascade of activation events. Human and mouse studies have shown that defective type I IFNs induction may hamper the ability to control viral infections. In humans, moderate to high-effect variants have been identified in individuals with particularly severe complications following viral infection. In mice, functional studies using knock-out alleles have revealed the specific role of most genes of the IFN pathway. Here, we review the role of the molecular partners of the type I IFNs induction pathway and their implication in the control of viral infections and of their complications.

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Animal genetics
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Dates and versions

pasteur-03017356 , version 1 (03-12-2020)

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Attribution - NonCommercial

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Marie Bourdon, Caroline Manet, Xavier Montagutelli. Host genetic susceptibility to viral infections: the role of type I interferon induction. Genes and Immunity, 2020, ⟨10.1038/s41435-020-00116-2⟩. ⟨pasteur-03017356⟩

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