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Journal Articles Nature Reviews Microbiology Year : 2015

Pathogen manipulation of B cells: the best defence is a good offence

Abstract

B cells have long been regarded as simple antibody production units, but are now becoming known as key players in both adaptive and innate immune responses. However, several bacteria, viruses and parasites have evolved the ability to manipulate B cell functions to modulate immune responses. Pathogens can affect B cells indirectly, by attacking innate immune cells and altering the cytokine environment, and can also target B cells directly, impairing B cell-mediated immune responses. In this Review, we provide a summary of recent advances in elucidating direct B cell-pathogen interactions and highlight how targeting this specific cell population benefits different pathogens.

Dates and versions

pasteur-02874942 , version 1 (19-06-2020)

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Katharina Nothelfer, Philippe Sansonetti, Armelle Phalipon. Pathogen manipulation of B cells: the best defence is a good offence. Nature Reviews Microbiology, 2015, 13 (3), pp.173-184. ⟨10.1038/nrmicro3415⟩. ⟨pasteur-02874942⟩

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