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Journal Articles Trends in Microbiology Year : 2018

Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors

Abstract

Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bacteria, including the human enteric pathogens Shigella, Salmonella, Yersinia, and enteropathogenic/enterohemorragic Escherichia coli (EPEC/EHEC). The emerging global view is that these T3SS-bearing pathogens share similarities in their ability to target key cellular pathways such as the cell cytoskeleton, trafficking, cell death/survival, and the NF-κB and MAPK signaling pathways. In particular, multiple host proteins are targeted in a given pathway, and different T3SS effectors from various pathogens share functional similarities.
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pasteur-02874893 , version 1 (19-06-2020)

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Laurie Pinaud, Philippe Sansonetti, Armelle Phalipon. Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors. Trends in Microbiology, 2018, 26 (4), pp.266-283. ⟨10.1016/j.tim.2018.01.010⟩. ⟨pasteur-02874893⟩

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