Neisseria meningitidis pili induce type-IIA phospholipase A 2 expression in alveolar macrophages - Institut Pasteur Access content directly
Journal Articles FEBS Letters Year : 2005

Neisseria meningitidis pili induce type-IIA phospholipase A 2 expression in alveolar macrophages

Abstract

Induction of type-IIA secreted phospholipase A2 (sPLA2-IIA) expression by bacterial components other than lipopolysaccharide has not been previously investigated. Here, we show that exposure of alveolar macrophages (AM) to Neisseria meningitidis or its lipooligosaccharide (LOS) induced sPLA2-IIA synthesis. However, N. meningitidis mutant devoid of LOS did not abolish this effect. In addition, a pili-defective mutant exhibited significantly lower capacity to stimulate sPLA2-IIA synthesis than the wild-type strain. Moreover, pili isolated from a LOS-defective strain induced sPLA2-IIA expression and nuclear factor kappa B (NF-kappaB) activation. These data suggest that pili are potent inducers of sPLA2-IIA expression by AM, through a NF-kappaB-dependent process.

Dates and versions

pasteur-02863049 , version 1 (09-06-2020)

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Cite

Lhousseine Touqui, Miguel Paya, Francoise Thouron, Annie Guiyoule, Maria-Leticia Zarantonelli, et al.. Neisseria meningitidis pili induce type-IIA phospholipase A 2 expression in alveolar macrophages. FEBS Letters, 2005, 579 (22), pp.4923-4927. ⟨10.1016/j.febslet.2005.06.067⟩. ⟨pasteur-02863049⟩

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