Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants - Institut Pasteur Access content directly
Journal Articles BioEssays Year : 2009

Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

Abstract

In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen.

Dates and versions

pasteur-02862992 , version 1 (09-06-2020)

Identifiers

Cite

Stephen Gordon, Daria Bottai, Roxane Simeone, Timothy P Stinear, Roland Brosch. Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants. BioEssays, 2009, 31 (4), pp.378-388. ⟨10.1002/bies.200800191⟩. ⟨pasteur-02862992⟩

Collections

PASTEUR
15 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More