Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes - Institut Pasteur Access content directly
Journal Articles Diabetologia Year : 2020

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes

Abstract

Self-antigen-specific T cell responses drive type 1 diabetes pathogenesis, but alterations in innate immune responses are also critical and not as well understood. Innate immunity in human type 1 diabetes has primarily been assessed via gene-expression analysis of unstimulated peripheral blood mononuclear cells, without the immune activation that could amplify disease-associated signals. Increased responsiveness in each of the two main innate immune pathways, driven by either type 1 IFN (IFN-1) or IL-1, have been detected in type 1 diabetes, but the dominant innate pathway is still unclear. This study aimed to determine the key innate pathway in type 1 diabetes and assess the whole blood immune stimulation assay as a tool to investigate this.

Dates and versions

pasteur-02860487 , version 1 (08-06-2020)

Identifiers

Cite

Kameron Rodrigues, Matthew Dufort, Alba Llibre, Cate Speake, M Jubayer Rahman, et al.. Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes. Diabetologia, 2020, ⟨10.1007/s00125-020-05179-4⟩. ⟨pasteur-02860487⟩

Collections

PASTEUR ANR
42 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More