Epigenetic clock analysis in long-term meditators - Institut Pasteur Access content directly
Journal Articles Psychoneuroendocrinology Year : 2017

Epigenetic clock analysis in long-term meditators


In this paper, we examined whether meditation practice influences the epigenetic clock, a strong and reproducible biomarker of biological aging, which is accelerated by cumulative lifetime stress and with age-related chronic diseases. Using the Illumina 450K array platform, we analyzed the DNA methylome from blood cells of long-term meditators and meditation-naïve controls to estimate their Intrinsic Epigenetic Age Acceleration (IEAA), using Horvath's calculator. IEAA was similar in both groups. However, controls showed a different IEAA trajectory with aging than meditators: older controls (age≥52) had significantly higher IEAAs compared with younger controls (age <52), while meditators were protected from this epigenetic aging effect. Notably, in the meditation group, we found a significant negative correlation between IEAA and the number of years of regular meditation practice. From our results, we hypothesize that the cumulative effects of a regular meditation practice may, in the long-term, help to slow the epigenetic clock and could represent a useful preventive strategy for age-related chronic diseases. Longitudinal randomized controlled trials in larger cohorts are warranted to confirm and further characterize these findings.


Human genetics

Dates and versions

pasteur-02555207 , version 1 (27-04-2020)



Raphaëlle Chaix, Maria Jesús Alvarez-López, Maud Fagny, Laure Lemee, Béatrice Regnault, et al.. Epigenetic clock analysis in long-term meditators. Psychoneuroendocrinology, 2017, 85, pp.210-214. ⟨10.1016/j.psyneuen.2017.08.016⟩. ⟨pasteur-02555207⟩
80 View
0 Download



Gmail Facebook Twitter LinkedIn More