Hospital discharges in urban sanitation systems: Long-term monitoring of wastewater resistome and microbiota in relationship to their eco-exposome
Résumé
Wastewaters (WW) are important sources for the dissemination of antimicrobial resistance (AMR) into the environment. Hospital WW (HWW) contain higher loads of micro-pollutants and AMR markers than urban WW (UWW). Little is known about the long-term dynamics of H and U WW and the impact of their joined treatment on the general burden of AMR. Here, we characterized the resistome, microbiota and eco-exposome signature of 126 H and U WW samples treated separately for three years, and then mixed, over one year. Multi-variate analysis and machine learning revealed a robust signature for each WW with no significant variation over time before mixing, and once mixed, both WW closely resembled Urban signatures. We demonstrated a significant impact of pharmaceuticals and surfactants on the resistome and microbiota of H and U WW. Our results present considerable targets for AMR related risk assessment of WW.
Mots clés
ARG
Antibiotic-Resistant Gene
ARB
Antibiotic-Resistant Bacteria
Resistome (ARGs and MGEs)
MGE
Microbiota
Mobile Genetic Element
Hospital and urban wastewater eco-exposome
UWW
Urban Wastewater
WW
Hospital Wastewater
Wastewater
Hospital and urban wastewater
HWW
Antimicrobial resistance
ARG
WW signatures
AMR
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Hospital discharges in urban sanitation systems.pdf (2.03 Mo)
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| Origine | Publication financée par une institution |
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