Immune Responses to Retroviruses - Institut Pasteur Access content directly
Journal Articles Annual Review of Immunology Year : 2018

Immune Responses to Retroviruses

Abstract

Retroviruses are genome invaders that have shared a long history of coevolution with vertebrates and their immune system. Found endogenously in genomes as traces of past invasions, retroviruses are also considerable threats to human health when they exist as exogenous viruses such as HIV. The immune response to retroviruses is engaged by germline-encoded sensors of innate immunity that recognize viral components and damage induced by the infection. This response develops with the induction of antiviral effectors and launching of the clonal adaptive immune response, which can contribute to protective immunity. However, retroviruses efficiently evade the immune response, owing to their rapid evolution. The failure of specialized immune cells to respond, a form of neglect, may also contribute to inadequate antiretroviral immune responses. Here, we discuss the mechanisms by which immune responses to retroviruses are mounted at the molecular, cellular, and organismal levels. We also discuss how intrinsic, innate, and adaptive immunity may cooperate or conflict during the generation of immune responses.
Fichier principal
Vignette du fichier
20160504 plan AnnRevimm v6.pdf (374.14 Ko) Télécharger le fichier
figure1.pdf (298.08 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Origin Files produced by the author(s)

Dates and versions

pasteur-02549874 , version 1 (21-04-2020)

Licence

Identifiers

Cite

Asier Saez-Cirion, Nicolas Manel. Immune Responses to Retroviruses. Annual Review of Immunology, 2018, 36, pp.193-220. ⟨10.1146/annurev-immunol-051116-052155⟩. ⟨pasteur-02549874⟩
294 View
686 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More