Complex phenotypes of a mutant inactivated for CymR, the global regulator of cysteine metabolism in Bacillus subtilis - Institut Pasteur Access content directly
Journal Articles FEMS Microbiology Letters Year : 2010

Complex phenotypes of a mutant inactivated for CymR, the global regulator of cysteine metabolism in Bacillus subtilis

Abstract

We characterized various phenotypes of a mutant inactivated for CymR, the master regulator of cysteine metabolism in Bacillus subtilis. The deletion of cymR resulted in impaired growth in the presence of cystine and increased sensitivity to hydrogen peroxide-, disulfide-, paraquat-and tellurite-induced stresses. Estimation of metabolite pools suggested that these phenotypes could be the result of profound metabolic changes in the DcymR mutant including an increase of the intracellular cysteine pool and hydrogen sulfide formation, as well as a depletion of branched-chain amino acids.

Dates and versions

pasteur-02436920 , version 1 (13-01-2020)

Identifiers

Cite

Marie-Françoise Hullo, Isabelle Martin-Verstraete, Olga Soutourina. Complex phenotypes of a mutant inactivated for CymR, the global regulator of cysteine metabolism in Bacillus subtilis. FEMS Microbiology Letters, 2010, 309 (2), pp.201-207. ⟨10.1111/j.1574-6968.2010.02043.x⟩. ⟨pasteur-02436920⟩

Collections

PASTEUR CNRS ANR
32 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More