The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease - Institut Pasteur Access content directly
Journal Articles Ageing Research Reviews - ARR Year : 2019

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. PD is characterized by the loss of dopaminergic neurons, primarily in brain regions that control motor functions, thereby leading to motor impairments in the patients. Pathological aggregated forms of the synaptic protein, α-synuclein (α-syn), are involved in the generation and progression of PD. In PD brains, α-syn accumulates inside neurons and propagates from cell-to-cell in a prion-like manner. In this review, we discuss the in vitro and in vivo models used to study the prion-like properties of α-syn and related findings. In particular, we focus on the different mechanisms of α-syn spreading, which could be relevant for the development of alternative therapeutic approaches for PD treatment.
Fichier principal
Vignette du fichier
S1568163718302617.pdf (671.77 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-02263600 , version 1 (21-10-2021)

Licence

Attribution - NonCommercial

Identifiers

Cite

Jessica Vargas, Clara Grudina, Chiara Zurzolo. The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease. Ageing Research Reviews - ARR, 2019, 50, pp.89-101. ⟨10.1016/j.arr.2019.01.012⟩. ⟨pasteur-02263600⟩
32 View
183 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More