The Shiverer Mutation Affects the Persistence of Theiler's Virus in the Central Nervous System - Institut Pasteur Access content directly
Journal Articles Journal of Virology Year : 1997

The Shiverer Mutation Affects the Persistence of Theiler's Virus in the Central Nervous System

Franck Bihl
Claudia Pena-Rossi
  • Function : Author
Michel Brahic
  • Function : Correspondent author
  • PersonId : 1045476

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Jean-François Bureau

Abstract

Theiler's virus persists in the white matter of the spinal cord of genetically susceptible mice and causes primary demyelination. The virus persists in macrophages/microglial cells, but also in oligodendrocytes, the myelin-forming cells. Susceptibility/resistance to this chronic infection has been mapped to several loci including one tentatively located in the telomeric region of chromosome 18, close to the myelin basic protein locus (Mbp locus). To determine if the MBP gene influences viral persistence, we inoculated C3H mice bearing the shiverer mutation, a 20-kb deletion in the gene. Whereas control C3H mice were of intermediate susceptibility , C3H mice heterozygous for the mutation were very susceptible, and those homozygous for the mutation were completely resistant. This resistance was not immune mediated. Furthermore, C3H/101H mice homozy-gous for a point mutation in the gene coding for the proteolipid protein of myelin, the rumpshaker mutation, were resistant. These results strongly support the view that oligodendrocytes are a necessary viral target for the establishment of a persistent infection by Theiler's virus.

Dates and versions

pasteur-02097165 , version 1 (11-04-2019)

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Franck Bihl, Claudia Pena-Rossi, Jean-Louis Guénet, Michel Brahic, Jean-François Bureau. The Shiverer Mutation Affects the Persistence of Theiler's Virus in the Central Nervous System. Journal of Virology, 1997, 71 (7), pp.5025 - 5030. ⟨pasteur-02097165⟩

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