Roles of the H-2D b and H-K b genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system - Institut Pasteur Access content directly
Journal Articles Journal of General Virology Year : 2001

Roles of the H-2D b and H-K b genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system

Sylvie Syan
  • Function : Author
Michel Brahic
  • Function : Correspondent author
  • PersonId : 1045476

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Jean-François Bureau

Abstract

Theiler's murine encephalomyelitis virus, a member of the Picornaviridae family, persists in the spinal cord of susceptible strains of mice. Resistant strains of mice, such as the H-2 b strain, clear the virus infection after an acute encephalomyelitis. The H-2D locus, but not the H-2K locus, has a major effect on this resistance, although both loci code for MHC class I molecules with similar general properties. For the present work, we rendered susceptible H-2 q FVB/N mice transgenic for either the H-2D b gene, the H-2K b gene or a chimeric H-2D b /K b gene in which the exons encoding the peptide-binding groove of the H-2K b gene have been replaced by those of the H-2D b gene. Mice transgenic for either the H-2D b gene or the chimeric H-2D b /K b gene were significantly more resistant to persistent virus infection than mice transgenic for the H-2K b gene, suggesting that the difference in the effects of the H-2D b gene and the H-2K b gene are due to the nature of the peptides presented by these class I molecules.

Dates and versions

pasteur-02097160 , version 1 (11-04-2019)

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Arièle Azoulay-Cayla, Sylvie Syan, Michel Brahic, Jean-François Bureau. Roles of the H-2D b and H-K b genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system. Journal of General Virology, 2001, 82, pp.1043 - 1047. ⟨10.1099/0022-1317-82-5-1043⟩. ⟨pasteur-02097160⟩

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