Viral Load and a Locus on Chromosome 11 Affect the Late Clinical Disease Caused by Theiler's Virus - Institut Pasteur Access content directly
Journal Articles Journal of Virology Year : 1999

Viral Load and a Locus on Chromosome 11 Affect the Late Clinical Disease Caused by Theiler's Virus

Stéphanie Aubagnac
  • Function : Author
Michel Brahic
  • Function : Correspondent author
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Jean-François Bureau

Abstract

Theiler's virus causes a persistent infection and a demyelinating disease of mice which is a model for multiple sclerosis. Susceptibility to viral persistence maps to several loci, including the interferon gamma locus. Inactivating the gene coding for the interferon gamma receptor makes 129/Sv mice susceptible to persistent infection and clinical disease, whereas inactivating the interferon gamma gene makes C57BL/6 mice susceptible to persistent infection but not to clinical disease. This difference in phenotype is due to the difference in genetic background. Clinical disease depends on high viral load and Tmevd5, a locus on chromosome 11. These results have consequences for the identification of viruses which might be implicated in multiple sclerosis.

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pasteur-02090472 , version 1 (04-04-2019)

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Stéphanie Aubagnac, Michel Brahic, Jean-François Bureau. Viral Load and a Locus on Chromosome 11 Affect the Late Clinical Disease Caused by Theiler's Virus. Journal of Virology, 1999, 73 (10), pp.7965 - 7971. ⟨pasteur-02090472⟩

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