GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics - Institut Pasteur Access content directly
Journal Articles Antiviral Research Year : 2019

GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

1 UVE - Unité des Virus Emergents
2 EA7310 - Laboratoire de Virologie [UNIV Corse-Inserm]
3 RIVM - National Institute for Public Health and the Environment [Bilthoven]
4 Erasmus MC - Erasmus University Medical Center [Rotterdam]
5 UTMB - The University of Texas Medical Branch
6 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
7 Humboldt-Universität zu Berlin - Humboldt University Of Berlin
8 BIH - Berlin Institute of Health
9 DZIF - German Centre for Infection Research
10 UC San Francisco - University of California [San Francisco]
11 Stanford School of Medicine [Stanford]
12 WUSTL - Washington University in Saint Louis
13 Public Health Agency of Canada
14 FIOCRUZ - Fundação Oswaldo Cruz / Oswaldo Cruz Foundation
15 UFBA - Universidade Federal da Bahia
16 University of Glasgow
17 Biologie des Infections - Biology of Infection
18 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
19 CHU Necker - Enfants Malades [AP-HP]
20 UPD5 - Université Paris Descartes - Paris 5
21 A*STAR - Agency for science, technology and research [Singapore]
22 EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée
23 Institut Pasteur du Cambodge
24 Institut Pasteur de Dakar
25 Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors
26 Heidelberg University Hospital [Heidelberg]
27 Rega Institute for Medical Research [Leuven, België]
28 FDA - U.S. Food and Drug Administration
29 UTP - Universidad Tecnológica de Pereira [Colombie]
30 Hôpital d'Instruction des Armées Laveran
31 Institut Pasteur de la Guadeloupe
A. Kohl
  • Function : Author
Sébastien Boyer


The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) Chikungunya (CHIKV), O'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group is investigating the natural history, epidemiology and medical management of infection by these viruses, to identify knowledge gaps and to propose recommendations for direct future investigations and rectification measures. Here, we present the first report dedicated to diagnostic aspects of CHIKV, ONNV and MAYV. Regarding diagnosis of the disease at the acute phase, molecular assays previously described for the three viruses require further evaluation, standardized protocols and the availability of international standards representing the genetic diversity of the viruses. Detection of specific IgM would benefit from further investigations to clarify the extent of cross-reactivity among the three viruses, the sensitivity of the assays, and the possible interfering role of cryoglobulinaemia. Implementation of reference panels and external quality assessments for both molecular and serological assays is necessary. Regarding sero-epidemiological studies, there is no reported high-throughput assay that can distinguish among these different viruses in areas of potential co-circulation. New specific tools and/or improved standardized protocols are needed to enable large-scale epidemiological studies of public health relevance to be performed. Considering the high risk of future CHIKV, MAYV and ONNV outbreaks, the Working Group recommends that a major investigation should be initiated to fill the existing diagnostic gaps.


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pasteur-02081240 , version 1 (27-03-2019)


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L. Pezzi, C.B. B Reusken, S.C. C Weaver, J.F. F Drexler, M. Busch, et al.. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics. Antiviral Research, 2019, 166, pp.66-81. ⟨10.1016/j.antiviral.2019.03.009⟩. ⟨pasteur-02081240⟩
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