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Journal Articles Chemical Communications Year : 2018

Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

Abstract

We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.
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pasteur-02012225 , version 1 (08-02-2019)

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Hien Bao Dieu Thai, Fabienne Levi-Acobas, Soo-Young Yum, Goo Jang, Marcel Hollenstein, et al.. Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity. Chemical Communications, 2018, 54 (68), pp.9410-9413. ⟨10.1039/c8cc05721d⟩. ⟨pasteur-02012225⟩
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